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Slc22a1 Gene Detail
Summary
  • Symbol
    Slc22a1
  • Name
    solute carrier family 22 (organic cation transporter), member 1
  • Synonyms
    Lx1, MGC:14019, Oct1, Oct1, Orct, Orct1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108111
    NCBI Gene: 20517
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:12867756-12894716 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.63 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    569 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108111
 protein coding gene Chr17:12867756-12894725 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023148
 protein coding gene Chr17:10312412-10339104 (-)
A/J MGP_AJ_G0023116
 protein coding gene Chr17:10139649-10167369 (-)
AKR/J MGP_AKRJ_G0023080
 protein coding gene Chr17:9968471-9995315 (-)
BALB/cJ MGP_BALBcJ_G0023116
 protein coding gene Chr17:9916250-9944075 (-)
C3H/HeJ MGP_C3HHeJ_G0022879
 protein coding gene Chr17:10214085-10243808 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023559
 protein coding gene Chr17:10703587-10730026 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021049
 protein coding gene Chr17:4277304-4303806 (+)
CAST/EiJ MGP_CASTEiJ_G0022393
 protein coding gene Chr17:10294794-10326474 (-)
CBA/J MGP_CBAJ_G0022851
 protein coding gene Chr17:11098187-11133562 (-)
DBA/2J MGP_DBA2J_G0022984
 protein coding gene Chr17:9777173-9809532 (-)
FVB/NJ MGP_FVBNJ_G0022954
 protein coding gene Chr17:9716374-9743091 (-)
LP/J MGP_LPJ_G0023056
 protein coding gene Chr17:10127697-10155803 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022973
 protein coding gene Chr17:10705880-10736731 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023585
 protein coding gene Chr17:10235818-10265277 (-)
PWK/PhJ MGP_PWKPhJ_G0022141
 protein coding gene Chr17:9470905-9498836 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021971
 protein coding gene Chr17:9665834-9694784 (-)
WSB/EiJ MGP_WSBEiJ_G0022450
 protein coding gene Chr17:10555332-10585827 (-)



Homology
more
  • Human Ortholog
    SLC22A1, solute carrier family 22 member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC22A1, solute carrier family 22 member 1
  • Synonyms
    HOCT1, OCT1, oct1_cds
  • Links
    NCBI Gene ID: 6580
    neXtProt AC: NX_O15245
    UniProt: O15245

  • Chr Location
    6q25.3; chr6:160121815-160158718 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele are viable, healthy, and fertile but exhibit an impaired liver uptake and direct intestinal excretion of substrate organic cations. Mice homozygous for a different knockout allele show alterations in metformin disposition and its glucose-lowering effects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    110
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    33
  • cDNA Data
    88
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023829 Ensembl Gene Model | MGI Sequence Detail 26961 C57BL/6J ±  kb
    transcript ENSMUST00000024596 Ensembl | MGI Sequence Detail 1985 Not Applicable  
    polypeptide ENSMUSP00000024596 Ensembl | MGI Sequence Detail 556 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 100
      Genomic 4
      cDNA 89
      Primer pair 6
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37054, MGD-MRK-37148
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 11
      Gene Ontology 15
      Phenotypes 15
    • Earliest
      J:35906 Schweifer N, et al., The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters. Mamm Genome. 1996 Oct;7(10):735-40
    • Latest
      J:339165 Hucke A, et al., Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin. Int J Mol Sci. 2023 Jul 14;24(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory