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Pxn Gene Detail
Summary
  • Symbol
    Pxn
  • Name
    paxillin
  • Synonyms
    Pax
  • Feature Type
    protein coding gene
  • IDs
    MGI:108295
    NCBI Gene: 19303
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:115644735-115694046 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1601 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108295
 protein coding gene Chr5:115630035-115694046 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029972
 protein coding gene Chr5:118403195-118454257 (+)
A/J MGP_AJ_G0029936
 protein coding gene Chr5:113681275-113732428 (+)
AKR/J MGP_AKRJ_G0029875
 protein coding gene Chr5:117321789-117376960 (+)
BALB/cJ MGP_BALBcJ_G0029947
 protein coding gene Chr5:115077539-115127020 (+)
C3H/HeJ MGP_C3HHeJ_G0029667
 protein coding gene Chr5:117840757-117894031 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030402
 protein coding gene Chr5:122955784-123007836 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027629
 protein coding gene Chr5:108454753-108505658 (+)
CAST/EiJ MGP_CASTEiJ_G0029076
 protein coding gene Chr5:116778257-116837141 (+)
CBA/J MGP_CBAJ_G0029635
 protein coding gene Chr5:127684023-127737024 (+)
DBA/2J MGP_DBA2J_G0029785
 protein coding gene Chr5:113770097-113820736 (+)
FVB/NJ MGP_FVBNJ_G0029741
 protein coding gene Chr5:112587105-112638317 (+)
LP/J MGP_LPJ_G0029873
 protein coding gene Chr5:118957474-119010324 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029772
 protein coding gene Chr5:131984872-132037476 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030443
 protein coding gene Chr5:116804701-116853965 (+)
PWK/PhJ MGP_PWKPhJ_G0028789
 protein coding gene Chr5:112415049-112465755 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028627
 protein coding gene Chr5:114351387-114400945 (+)
WSB/EiJ MGP_WSBEiJ_G0029151
 protein coding gene Chr5:117401909-117451415 (+)



Homology
more
  • Human Ortholog
    PXN, paxillin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PXN, paxillin
  • Links
    NCBI Gene ID: 5829
    neXtProt AC: NX_P49023
    UniProt: P49023

  • Chr Location
    12q24.23; chr12:120210439-120265771 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die at E9.5 with defects in the amnion, allantois, and headfold structures, as well as impaired growth, and abnormal heart and somite development; mutant fibroblasts show aberrant fibronectin-regulated focal adhesion dynamics, and disorganized membrane cytoskeletal structures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    949
  • Tissues
    96
  • cDNA Data
    87
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029528 Ensembl Gene Model | MGI Sequence Detail 49312 C57BL/6J ±  kb
    transcript ENSMUST00000212819 Ensembl | MGI Sequence Detail 3189 Not Applicable  
    polypeptide ENSMUSP00000148843 Ensembl | MGI Sequence Detail 1062 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      Genomic 8
      cDNA 88
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37334, MGI:2141153, MGI:2141158
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 34
      Gene Ontology 27
      Phenotypes 26
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:358300 Zhang Y, et al., Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation. Cell Commun Signal. 2024 Jan 22;22(1):58
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory