About   Help   FAQ
Vnn1 Gene Detail
Summary
  • Symbol
    Vnn1
  • Name
    vanin 1
  • Synonyms
    pantetheinase, V-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108395
    NCBI Gene: 22361
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:23770586-23781241 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 11.33 cM, cytoband A1-B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    354 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108395
 protein coding gene Chr10:23770586-23781242 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017075
 protein coding gene Chr10:21823914-21835602 (+)
A/J MGP_AJ_G0017053
 protein coding gene Chr10:21185365-21195943 (+)
AKR/J MGP_AKRJ_G0017015
 protein coding gene Chr10:21530292-21540866 (+)
BALB/cJ MGP_BALBcJ_G0017015
 protein coding gene Chr10:21259265-21269794 (+)
C3H/HeJ MGP_C3HHeJ_G0016835
 protein coding gene Chr10:21735505-21747523 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017473
 protein coding gene Chr10:22466273-22484614 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015174
 protein coding gene Chr10:19915480-19926296 (+)
CAST/EiJ MGP_CASTEiJ_G0016416
 protein coding gene Chr10:21632029-21642764 (+)
CBA/J MGP_CBAJ_G0016808
 protein coding gene Chr10:23469331-23484946 (+)
DBA/2J MGP_DBA2J_G0016914
 protein coding gene Chr10:20922602-20938004 (+)
FVB/NJ MGP_FVBNJ_G0016910
 protein coding gene Chr10:20640581-20653045 (+)
LP/J MGP_LPJ_G0016990
 protein coding gene Chr10:21804370-21822941 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016940
 protein coding gene Chr10:23612678-23624719 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017508
 protein coding gene Chr10:21398149-21410980 (+)
PWK/PhJ MGP_PWKPhJ_G0016201
 protein coding gene Chr10:20664841-20675692 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015983
 protein coding gene Chr10:21210603-21220885 (+)
WSB/EiJ MGP_WSBEiJ_G0016479
 protein coding gene Chr10:21497826-21509086 (+)



Homology
more
  • Human Ortholog
    VNN1, vanin 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VNN1, vanin 1
  • Synonyms
    HDLCQ8, Tiff66
  • Links
    NCBI Gene ID: 8876
    neXtProt AC: NX_O95497
    UniProt: O95497

  • Chr Location
    6q23.2; chr6:132680849-132714055 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene develop normally and so no abnormalities in the maturation of lymphoid organs. However, membrane bound pantetheinase is absent in livers and kidneys resuulting in an absence of cysteamine in these organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    892
  • Tissues
    130
  • cDNA Data
    25
  • Literature Summary
    15
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037440 Ensembl Gene Model | MGI Sequence Detail 10656 C57BL/6J ±  kb
transcript ENSMUST00000041416 Ensembl | MGI Sequence Detail 2416 Not Applicable  
polypeptide ENSMUSP00000040599 Ensembl | MGI Sequence Detail 512 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    Genomic 1
    cDNA 26
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-37437
References
more
  • Summaries
    All 74
    Developmental Gene Expression 15
    Gene Ontology 12
    Phenotypes 25
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory