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Arhgdig Gene Detail
Summary
  • Symbol
    Arhgdig
  • Name
    Rho GDP dissociation inhibitor gamma
  • Synonyms
    Gdi5, Rho-GDI2, Rho-GDI-3, RIP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108430
    NCBI Gene: 14570
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:26418157-26420324 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 13.07 cM
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108430
 protein coding gene Chr17:26418157-26426760 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023394
 protein coding gene Chr17:25343398-25354932 (-)
A/J MGP_AJ_G0023353
 protein coding gene Chr17:24587438-24598996 (-)
AKR/J MGP_AKRJ_G0023319
 protein coding gene Chr17:24698487-24710048 (-)
BALB/cJ MGP_BALBcJ_G0023358
 protein coding gene Chr17:24808712-24820283 (-)
C3H/HeJ MGP_C3HHeJ_G0023118
 protein coding gene Chr17:25090726-25102284 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023800
 protein coding gene Chr17:26407046-26418655 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021276
 protein coding gene Chr17:22046427-22058013 (-)
CAST/EiJ MGP_CASTEiJ_G0022620
 protein coding gene Chr17:24998496-25010057 (-)
CBA/J MGP_CBAJ_G0023093
 protein coding gene Chr17:27343112-27354700 (-)
DBA/2J MGP_DBA2J_G0023223
 protein coding gene Chr17:24180764-24192317 (-)
FVB/NJ MGP_FVBNJ_G0023193
 protein coding gene Chr17:23943237-23954792 (-)
LP/J MGP_LPJ_G0023300
 protein coding gene Chr17:25622055-25633597 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023212
 protein coding gene Chr17:26913150-26924702 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023840
 protein coding gene Chr17:25048907-25060465 (-)
PWK/PhJ MGP_PWKPhJ_G0022369
 protein coding gene Chr17:22951198-22962849 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022187
 protein coding gene Chr17:23115724-23127246 (-)
WSB/EiJ MGP_WSBEiJ_G0022683
 protein coding gene Chr17:25070323-25081883 (-)



Homology
more
  • Human Ortholog
    ARHGDIG, Rho GDP dissociation inhibitor gamma
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGDIG, Rho GDP dissociation inhibitor gamma
  • Synonyms
    RHOGDI-3
  • Links
    NCBI Gene ID: 398
    neXtProt AC: NX_Q99819
    UniProt: Q99819

  • Chr Location
    16p13.3; chr16:280450-283010 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Homozygous null mice are fertile and exhibit no physical, behavioral, learning, or sleep abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    915
  • Tissues
    60
  • cDNA Data
    32
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14570 NCBI Gene Model | MGI Sequence Detail 2168 C57BL/6J ±  kb
transcript NM_008113 RefSeq | MGI Sequence Detail 1032 C57BL/6  
polypeptide Q62160 UniProt | EBI | MGI Sequence Detail 225 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 32
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37474
References
more
  • Summaries
    All 37
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:36812 Zalcman G, et al., RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. J Biol Chem. 1996 29;271(48):30366-74
  • Latest
    J:304253 Jones MR, et al., A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Front Genet. 2018;9:746
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory