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Ntan1 Gene Detail
Summary
  • Symbol
    Ntan1
  • Name
    N-terminal Asn amidase
  • Synonyms
    asparagine-specific N-terminal amidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:108471
    NCBI Gene: 18203
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:13636709-13653315 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 9.64 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108471
 protein coding gene Chr16:13636629-13653315 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022536
 protein coding gene Chr16:10818888-10848400 (+)
A/J MGP_AJ_G0022498
 protein coding gene Chr16:10227949-10243696 (+)
AKR/J MGP_AKRJ_G0022474
 protein coding gene Chr16:10673279-10689445 (+)
BALB/cJ MGP_BALBcJ_G0022502
 protein coding gene Chr16:10391857-10410346 (+)
C3H/HeJ MGP_C3HHeJ_G0022269
 protein coding gene Chr16:10766038-10782667 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022951
 protein coding gene Chr16:10982830-11000158 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020471
 protein coding gene Chr16:10317976-10333307 (+)
CAST/EiJ MGP_CASTEiJ_G0021796
 protein coding gene Chr16:10783747-10801445 (+)
CBA/J MGP_CBAJ_G0022238
 protein coding gene Chr16:11514878-11535369 (+)
DBA/2J MGP_DBA2J_G0022369
 protein coding gene Chr16:10216599-10232604 (+)
FVB/NJ MGP_FVBNJ_G0022345
 protein coding gene Chr16:10203762-10219395 (+)
LP/J MGP_LPJ_G0022437
 protein coding gene Chr16:10727609-10743803 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022367
 protein coding gene Chr16:11138669-11157988 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022964
 protein coding gene Chr16:10648349-10665874 (+)
PWK/PhJ MGP_PWKPhJ_G0021538
 protein coding gene Chr16:10482297-10498392 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021366
 protein coding gene Chr16:10638334-10654111 (+)
WSB/EiJ MGP_WSBEiJ_G0021844
 protein coding gene Chr16:10664659-10689728 (+)



Homology
more
  • Human Ortholog
    NTAN1, N-terminal asparagine amidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTAN1, N-terminal asparagine amidase
  • Synonyms
    PNAA, PNAD
  • Links
    NCBI Gene ID: 123803
    neXtProt AC: NX_Q96AB6
    UniProt: Q96AB6

  • Chr Location
    16p13.11; chr16:15037854-15056079 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit behavioral and learning defects including abnormal spontaneous activity, impaired spatial memory, and reduced exploratory activity in the presence of conspecifics.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    892
  • Tissues
    150
  • cDNA Data
    19
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022681 Ensembl Gene Model | MGI Sequence Detail 16607 C57BL/6J ±  kb
transcript ENSMUST00000023362 Ensembl | MGI Sequence Detail 1175 Not Applicable  
polypeptide ENSMUSP00000023362 Ensembl | MGI Sequence Detail 310 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    Genomic 3
    cDNA 20
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37515
References
more
  • Summaries
    All 37
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:36619 Grigoryev S, et al., A mouse amidase specific for N-terminal asparagine. The gene, the enzyme, and their function in the N-end rule pathway. J Biol Chem. 1996 Nov 8;271(45):28521-32
  • Latest
    J:310429 Furtado GC, et al., TNFalpha-dependent development of lymphoid tissue in the absence of RORgammat+ lymphoid tissue inducer cells. Mucosal Immunol. 2014;7(3):602-14
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory