Meis2 MGI Mouse Gene Detail - MGI:108564

Symbol

Meis2
Name

Meis homeobox 2
Synonyms

A430109D20Rik, Meis2, Mrg1, Stra10

Feature Type

protein coding gene
IDs

MGI:108564
NCBI Gene: 17536
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr2:115693545-115896320 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 58.28 cM
Mapping Data

4 experiments

SNPs within 2kb

4199 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108564	protein coding gene	Chr2:115691745-115897925 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026306	protein coding gene	Chr2:118427438-118633533 (-)
A/J	MGP_AJ_G0026267	protein coding gene	Chr2:113633370-113837164 (-)
AKR/J	MGP_AKRJ_G0026246	protein coding gene	Chr2:116791138-116998872 (-)
BALB/cJ	MGP_BALBcJ_G0026280	protein coding gene	Chr2:113869960-114073582 (-)
C3H/HeJ	MGP_C3HHeJ_G0026025	protein coding gene	Chr2:117217364-117425259 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026727	protein coding gene	Chr2:122334228-122542284 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024107	protein coding gene	Chr2:108748644-108956333 (-)
CAST/EiJ	MGP_CASTEiJ_G0025488	protein coding gene	Chr2:117525562-117744152 (-)
CBA/J	MGP_CBAJ_G0026002	protein coding gene	Chr2:126639073-126856335 (-)
DBA/2J	MGP_DBA2J_G0026141	protein coding gene	Chr2:113062201-113265662 (-)
FVB/NJ	MGP_FVBNJ_G0026103	protein coding gene	Chr2:111903263-112105847 (-)
LP/J	MGP_LPJ_G0026242	protein coding gene	Chr2:118732425-118937563 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026122	protein coding gene	Chr2:131080147-131291443 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026782	protein coding gene	Chr2:116893671-117102998 (-)
PWK/PhJ	MGP_PWKPhJ_G0025224	protein coding gene	Chr2:112617463-112823799 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025023	protein coding gene	Chr2:116030471-116239764 (-)
WSB/EiJ	MGP_WSBEiJ_G0025557	protein coding gene	Chr2:117707668-117913496 (-)

Human Ortholog

MEIS2, Meis homeobox 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MEIS2, Meis homeobox 2
Synonyms

CPCMR, HsT18361, MRG1
Links

HGNC:7001

NCBI Gene ID: 4212

neXtProt AC: NX_O14770

UniProt: O14770
Chr Location

15q14; chr15:36889204-37101311 (-) GRCh38

MGI Vertebrate Homology

Meis2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MEIS2
Gene Tree

Meis2

Diseases

5 with human MEIS2 associations

				Human Disease	Mouse Models
				cleft palate IDs cleft palate DOID:674 ICD10CM:Q35 ICD9CM:749.0 ICD9CM:749.00 MESH:D002972 NCI:C87069 ORDO:99772 UMLS_CUI:C0008925
				cleft palate, cardiac defects, and intellectual disabillity IDs cleft palate, cardiac defects, and intellectual disabillity DOID:0111697 MESH:C563414 OMIM:600987 UMLS_CUI:C1832950
				learning disability IDs learning disability DOID:8927 DOID:2847 ICD10CM:F81.9 MESH:D007859 NCI:C89334 UMLS_CUI:C0023186 UMLS_CUI:C0751265
				open-angle glaucoma IDs open-angle glaucoma DOID:1067 EFO:0004190 ICD10CM:H40.1 ICD9CM:365.1 ICD9CM:365.10 ICD9CM:365.13 MESH:D005902 NCI:C34641 OMIM:137750 OMIM:177700 OMIM:602429 OMIM:603383 OMIM:606689 OMIM:608695 OMIM:608696 OMIM:609745 OMIM:609887 OMIM:610535 OMIM:611274 OMIM:611276 OMIM:613100 UMLS_CUI:C0017612
				orofacial cleft IDs orofacial cleft DOID:0050567 OMIM:PS119530

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

31 phenotypes from 2 alleles in 2 genetic backgrounds
24 phenotypes from multigenic genotypes
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

9
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Meis2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display early fetal lethality with hemorrhaging, persistent truncus arteriosis, absence of cardic valves and defects in other neural crest cell derived tissues.

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All GO Annotations

33
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1404
Tissues

435
cDNA Data

43
Literature Summary

166

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MEIS2

Xenbase meis2

ZFIN meis2a, meis2b

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All Sequences

176
RefSeq

62
UniProt

7
CCDS

CCDS16568.1, CCDS50664.1, CCDS50665.1, CCDS50666.1, CCDS50667.1, CCDS50668.1

Ensembl

ENSMUSG00000027210 (Evidence)
NCBI Gene

17536

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027210	Ensembl Gene Model \| MGI Sequence Detail	202776	C57BL/6J	± kb
transcript	ENSMUST00000028639	Ensembl \| MGI Sequence Detail	2831	Not Applicable
polypeptide	ENSMUSP00000028639	Ensembl \| MGI Sequence Detail	477	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010317 homeobox protein Meis2

(term hierarchy)
InterPro Domains

IPR001356 Homeobox domain

IPR008422 Homeobox KN domain

IPR009057 Homeobox-like domain superfamily

IPR032453 Homeobox protein PKNOX/Meis, N-terminal

IPR050224 Three Amino acid Loop Extension (TALE) homeobox

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All nucleic 69

Genomic 1

cDNA 44

Primer pair 8

Other 16

Microarray probesets 4

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MGD-MRK-36505, MGD-MRK-37608, MGI:107925, MGI:2442113

Summaries

All 213

Developmental Gene Expression 166

Gene Ontology 16

Phenotypes 24
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:354180 Xu M, et al., ISL1 and POU4F1 Directly Interact to Regulate the Differentiation and Survival of Inner Ear Sensory Neurons. J Neurosci. 2024 Feb 21;44(8)

TSS for Meis2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25733	Chr2:115896515-115896544 (-)	-210 bp
Tssr25732	Chr2:115896425-115896446 (-)	-116 bp
Tssr25731	Chr2:115896279-115896334 (-)	13 bp
Tssr25730	Chr2:115896266-115896277 (-)	48 bp
Tssr25729	Chr2:115896199-115896216 (-)	112 bp
Tssr25728	Chr2:115896172-115896186 (-)	141 bp
Tssr25727	Chr2:115896154-115896170 (-)	158 bp
Tssr25726	Chr2:115896126-115896137 (-)	188 bp
Tssr25725	Chr2:115895698-115895719 (-)	611 bp
Tssr25724	Chr2:115895609-115895614 (-)	708 bp
Tssr25723	Chr2:115895240-115895252 (-)	1,074 bp
Tssr25722	Chr2:115895214-115895230 (-)	1,098 bp
Tssr25721	Chr2:115895039-115895079 (-)	1,261 bp
Tssr25720	Chr2:115894329-115894381 (-)	1,965 bp
Tssr25719	Chr2:115892995-115893043 (-)	3,301 bp
Tssr25718	Chr2:115889269-115889280 (-)	7,045 bp
Tssr25717	Chr2:115879590-115879610 (-)	16,720 bp
Tssr25716	Chr2:115848741-115848746 (-)	47,576 bp
Tssr25715	Chr2:115830665-115830674 (-)	65,650 bp
Tssr25714	Chr2:115750265-115750268 (-)	146,053 bp
Tssr25713	Chr2:115725031-115725035 (-)	171,287 bp
Tssr25712	Chr2:115694805-115694819 (-)	201,508 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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