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Timp4 Gene Detail
Summary
  • Symbol
    Timp4
  • Name
    tissue inhibitor of metalloproteinase 4
  • Synonyms
    TIMP-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109125
    NCBI Gene: 110595
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:115221405-115229166 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.29 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    228 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109125
 protein coding gene Chr6:115218853-115229166 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031147
 protein coding gene Chr6:117852491-117864500 (-)
A/J MGP_AJ_G0031116
 protein coding gene Chr6:113327130-113337442 (-)
AKR/J MGP_AKRJ_G0031047
 protein coding gene Chr6:116384207-116394513 (-)
BALB/cJ MGP_BALBcJ_G0031127
 protein coding gene Chr6:113141939-113152242 (-)
C3H/HeJ MGP_C3HHeJ_G0030583
 protein coding gene Chr6:67907675-67917988 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031586
 protein coding gene Chr6:120854201-120864557 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028750
 protein coding gene Chr6:110345521-110356298 (-)
CAST/EiJ MGP_CASTEiJ_G0030234
 protein coding gene Chr6:116733270-116743570 (-)
CBA/J MGP_CBAJ_G0030813
 protein coding gene Chr6:125616729-125627015 (-)
DBA/2J MGP_DBA2J_G0030966
 protein coding gene Chr6:112261852-112272127 (-)
FVB/NJ MGP_FVBNJ_G0030920
 protein coding gene Chr6:111425497-111435833 (-)
LP/J MGP_LPJ_G0031046
 protein coding gene Chr6:117868424-117878746 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030954
 protein coding gene Chr6:129806759-129817082 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031613
 protein coding gene Chr6:116393343-116403633 (-)
PWK/PhJ MGP_PWKPhJ_G0029950
 protein coding gene Chr6:111260073-111270526 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029778
 protein coding gene Chr6:115091896-115102067 (-)
WSB/EiJ MGP_WSBEiJ_G0030318
 protein coding gene Chr6:116637937-116648243 (-)



Homology
more
  • Human Ortholog
    TIMP4, TIMP metallopeptidase inhibitor 4
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIMP4, TIMP metallopeptidase inhibitor 4
  • Synonyms
    TIMP-4
  • Links
    NCBI Gene ID: 7079
    neXtProt AC: NX_Q99727
    UniProt: Q99727

  • Chr Location
    3p25.2; chr3:12153068-12158912 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TIMP4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show increased lethality associated with left ventricle rupture following left anterior descending coronary artery ligation. Aged mice exhibit reduced myocardial performance index, decreased coronary flow rate, and increased left ventricle thickness and weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    37
  • cDNA Data
    11
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110595 NCBI Gene Model | MGI Sequence Detail 7762 C57BL/6J ±  kb
    transcript NM_080639 RefSeq | MGI Sequence Detail 2944 ZRU/MplStud  
    polypeptide Q9JHB3 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38169
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:48116 Greene J, et al., Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4. J Biol Chem. 1996 Nov 29;271(48):30375-80
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory