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Snap91 Gene Detail
Summary
  • Symbol
    Snap91
  • Name
    synaptosomal-associated protein 91
  • Synonyms
    91kDa, AP180, F1-20, mKIAA0656
  • Feature Type
    protein coding gene
  • IDs
    MGI:109132
    NCBI Gene: 20616
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:86647976-86762707 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 46.58 cM, cytoband E3.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3085 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109132
 protein coding gene Chr9:86647976-86762766 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035100
 protein coding gene Chr9:87618788-87737015 (-)
A/J MGP_AJ_G0035081
 protein coding gene Chr9:84555867-84670031 (-)
AKR/J MGP_AKRJ_G0035009
 protein coding gene Chr9:86567950-86682863 (-)
BALB/cJ MGP_BALBcJ_G0035069
 protein coding gene Chr9:84199136-84314821 (-)
C3H/HeJ MGP_C3HHeJ_G0034781
 protein coding gene Chr9:87026645-87142579 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035593
 protein coding gene Chr9:89981217-90103818 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032500
 protein coding gene Chr9:83327784-83445006 (-)
CAST/EiJ MGP_CASTEiJ_G0034099
 protein coding gene Chr9:87486909-87608669 (-)
CBA/J MGP_CBAJ_G0034754
 protein coding gene Chr9:93139433-93254488 (-)
DBA/2J MGP_DBA2J_G0034912
 protein coding gene Chr9:84114259-84230259 (-)
FVB/NJ MGP_FVBNJ_G0034855
 protein coding gene Chr9:83198314-83313278 (-)
LP/J MGP_LPJ_G0034993
 protein coding gene Chr9:87834459-87952982 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034897
 protein coding gene Chr9:94761386-94884151 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035613
 protein coding gene Chr9:86673016-86792702 (-)
PWK/PhJ MGP_PWKPhJ_G0033803
 protein coding gene Chr9:84281251-84397777 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033639
 protein coding gene Chr9:86873394-86990295 (-)
WSB/EiJ MGP_WSBEiJ_G0034216
 protein coding gene Chr9:86708336-86827856 (-)



Homology
more
  • Human Ortholog
    SNAP91, synaptosome associated protein 91
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNAP91, synaptosome associated protein 91
  • Synonyms
    AP180, CALM
  • Links
    NCBI Gene ID: 9892
    neXtProt AC: NX_O60641
    UniProt: O60641

  • Chr Location
    6q14.2; chr6:83552880-83709691 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display postnatal growth retardation, limb clasping, altered behavior, defects in synaptic vesicle reformation, impaired neurotransmission, excitatory/inhibitory imbalance, epileptic seizures, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1191
  • Tissues
    139
  • cDNA Data
    31
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033419 Ensembl Gene Model | MGI Sequence Detail 114732 C57BL/6J ±  kb
    transcript ENSMUST00000074468 Ensembl | MGI Sequence Detail 4336 Not Applicable  
    polypeptide ENSMUSP00000074066 Ensembl | MGI Sequence Detail 901 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 31
      Primer pair 7
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38176
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 11
    • Earliest
      J:1152 Zhou S, et al., Characterization of a novel synapse-specific protein. II. cDNA cloning and sequence analysis of the F1-20 protein. J Neurosci. 1992 Jun;12(6):2144-55
    • Latest
      J:325702 Azarnia Tehran D, et al., Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity. Sci Adv. 2022 May 27;8(21):eabl5032
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory