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Mnt Gene Detail
Summary
  • Symbol
    Mnt
  • Name
    max binding protein
  • Synonyms
    bHLHd3, Rox
  • Feature Type
    protein coding gene
  • IDs
    MGI:109150
    NCBI Gene: 17428
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:74721746-74736551 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.76 cM, cytoband B-C
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109150
 protein coding gene Chr11:74721651-74736551 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018699
 protein coding gene Chr11:75545246-75562004 (+)
A/J MGP_AJ_G0018665
 protein coding gene Chr11:72746890-72761691 (+)
AKR/J MGP_AKRJ_G0018635
 protein coding gene Chr11:74952539-74968441 (+)
BALB/cJ MGP_BALBcJ_G0018639
 protein coding gene Chr11:73114340-73129123 (+)
C3H/HeJ MGP_C3HHeJ_G0018452
 protein coding gene Chr11:74956285-74970249 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019090
 protein coding gene Chr11:77917547-77930867 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016725
 protein coding gene Chr11:69772099-69787159 (+)
CAST/EiJ MGP_CASTEiJ_G0018006
 protein coding gene Chr11:75332270-75348556 (+)
CBA/J MGP_CBAJ_G0018422
 protein coding gene Chr11:81339277-81354962 (+)
DBA/2J MGP_DBA2J_G0018531
 protein coding gene Chr11:72345990-72358508 (+)
FVB/NJ MGP_FVBNJ_G0018521
 protein coding gene Chr11:71916886-71931577 (+)
LP/J MGP_LPJ_G0018602
 protein coding gene Chr11:76143686-76156149 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018547
 protein coding gene Chr11:81946751-81961535 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019130
 protein coding gene Chr11:75144858-75159576 (+)
PWK/PhJ MGP_PWKPhJ_G0017777
 protein coding gene Chr11:73044042-73058903 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017568
 protein coding gene Chr11:74712380-74728560 (+)
WSB/EiJ MGP_WSBEiJ_G0018059
 protein coding gene Chr11:74950451-74965235 (+)



Homology
more
  • Human Ortholog
    MNT, MAX network transcriptional repressor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MNT, MAX network transcriptional repressor
  • Synonyms
    bHLHd3, lncRNA-HAL, MAD6, MXD6, ROX
  • Links
    NCBI Gene ID: 4335
    neXtProt AC: NX_Q99583
    UniProt: Q99583

  • Chr Location
    17p13.3; chr17:2384073-2401104 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mnt mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 4 alleles in 4 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygotes for a targeted null mutation are runted at birth and die within a few days, while mutant fibroblasts show abnormal cell cycling. Those homozygotes that survive are fertile and attain normal Heterozygotes for a conditional mammary epithelial specific knockout develop adenocarcinomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    93
  • cDNA Data
    76
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000282 Ensembl Gene Model | MGI Sequence Detail 14806 C57BL/6J ±  kb
    transcript ENSMUST00000000291 Ensembl | MGI Sequence Detail 4590 Not Applicable  
    polypeptide ENSMUSP00000000291 Ensembl | MGI Sequence Detail 591 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000010500 Max-binding protein MNT
      (term hierarchy)
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    • GlyGen
      O08789 4 sites, 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 82
      Genomic 3
      cDNA 77
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38194
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 6
      Phenotypes 25
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:334557 Nguyen HV, et al., MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis. Cell Death Differ. 2023 Apr;30(4):1018-1032
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory