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Grk5 Gene Detail
Summary
  • Symbol
    Grk5
  • Name
    G protein-coupled receptor kinase 5
  • Synonyms
    Gprk5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109161
    NCBI Gene: 14773
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:60878187-61084406 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 56.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3627 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109161
 protein coding gene Chr19:60877995-61084406 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025299
 protein coding gene Chr19:61503875-61699661 (+)
A/J MGP_AJ_G0025275
 protein coding gene Chr19:58497702-58698974 (+)
AKR/J MGP_AKRJ_G0025244
 protein coding gene Chr19:60328936-60527248 (+)
BALB/cJ MGP_BALBcJ_G0025270
 protein coding gene Chr19:58579357-58774560 (+)
C3H/HeJ MGP_C3HHeJ_G0025030
 protein coding gene Chr19:60566544-60767534 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025713
 protein coding gene Chr19:62957619-63161758 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023125
 protein coding gene Chr19:57319137-57514649 (+)
CAST/EiJ MGP_CASTEiJ_G0024495
 protein coding gene Chr19:60672457-60880323 (+)
CBA/J MGP_CBAJ_G0025010
 protein coding gene Chr19:66021967-66238828 (+)
DBA/2J MGP_DBA2J_G0025142
 protein coding gene Chr19:58283380-58475500 (+)
FVB/NJ MGP_FVBNJ_G0025103
 protein coding gene Chr19:57950754-58143662 (+)
LP/J MGP_LPJ_G0025228
 protein coding gene Chr19:61338201-61531309 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025136
 protein coding gene Chr19:65217517-65427327 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025771
 protein coding gene Chr19:60564834-60768550 (+)
PWK/PhJ MGP_PWKPhJ_G0024243
 protein coding gene Chr19:58224370-58421074 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024046
 protein coding gene Chr19:59215239-59437603 (+)
WSB/EiJ MGP_WSBEiJ_G0024565
 protein coding gene Chr19:60676281-60879216 (+)



Homology
more
  • Human Ortholog
    GRK5, G protein-coupled receptor kinase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRK5, G protein-coupled receptor kinase 5
  • Synonyms
    FP2025, GPRK5
  • Links
    NCBI Gene ID: 2869
    neXtProt AC: NX_P34947
    UniProt: P34947

  • Chr Location
    10q26.11; chr10:119207571-119459745 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 6 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in a decrease in thermal pain sensation. Mice homozygous for a knock-out allele exhibit decreased response of heart to induced stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    940
  • Tissues
    120
  • cDNA Data
    10
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003228 Ensembl Gene Model | MGI Sequence Detail 206220 C57BL/6J ±  kb
    transcript ENSMUST00000003313 Ensembl | MGI Sequence Detail 6580 Not Applicable  
    polypeptide ENSMUSP00000003313 Ensembl | MGI Sequence Detail 590 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 10
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38205
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 41
    • Earliest
      J:36567 Jaber M, et al., Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12974-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory