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Ccn3 Gene Detail
Summary
  • Symbol
    Ccn3
  • Name
    cellular communication network factor 3
  • Synonyms
    C130088N23Rik, CCN3, Nov
  • Feature Type
    protein coding gene
  • IDs
    MGI:109185
    NCBI Gene: 18133
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:54609306-54617158 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 21.49 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    349 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109185
 protein coding gene Chr15:54609098-54617435 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021849
 protein coding gene Chr15:53795938-53805573 (+)
A/J MGP_AJ_G0021809
 protein coding gene Chr15:51660978-51670208 (+)
AKR/J MGP_AKRJ_G0021790
 protein coding gene Chr15:53126674-53134809 (+)
BALB/cJ MGP_BALBcJ_G0021816
 protein coding gene Chr15:51893702-51902306 (+)
C3H/HeJ MGP_C3HHeJ_G0021590
 protein coding gene Chr15:53212773-53220958 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022255
 protein coding gene Chr15:55884515-55892764 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019792
 protein coding gene Chr15:48913938-48922008 (+)
CAST/EiJ MGP_CASTEiJ_G0021107
 protein coding gene Chr15:53778710-53787949 (+)
CBA/J MGP_CBAJ_G0021559
 protein coding gene Chr15:57904485-57912712 (+)
DBA/2J MGP_DBA2J_G0021683
 protein coding gene Chr15:51562213-51571449 (+)
FVB/NJ MGP_FVBNJ_G0021661
 protein coding gene Chr15:50687883-50696261 (+)
LP/J MGP_LPJ_G0021753
 protein coding gene Chr15:53596094-53604151 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021685
 protein coding gene Chr15:62964054-62974376 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022278
 protein coding gene Chr15:53468911-53477076 (+)
PWK/PhJ MGP_PWKPhJ_G0020852
 protein coding gene Chr15:51621424-51630391 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020689
 protein coding gene Chr15:53193083-53202912 (+)
WSB/EiJ MGP_WSBEiJ_G0021162
 protein coding gene Chr15:53460344-53469562 (+)



Homology
more
  • Human Ortholog
    CCN3, cellular communication network factor 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCN3, cellular communication network factor 3
  • Synonyms
    IBP-9, IGFBP-9, IGFBP9, NOV, NOVh
  • Links
    NCBI Gene ID: 4856
    neXtProt AC: NX_P48745
    UniProt: P48745

  • Chr Location
    8q24.12; chr8:119416446-119424434 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 4 alleles in 4 genetic backgrounds
    5 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Heterozygotes and homozygotes for a null mutation exhibit abnormal skeletal and cardiac development, muscle atrophy and cataracts. Mice homozygous for another knock-out allele exhibit minor bone structure and physiology defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    891
  • Tissues
    151
  • cDNA Data
    31
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18133 NCBI Gene Model | MGI Sequence Detail 7853 C57BL/6J ±  kb
    transcript NM_010930 RefSeq | MGI Sequence Detail 2384 ZRU/MplStud  
    polypeptide Q64299 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011338 protein NOV
      (term hierarchy)
    • InterPro Domains
      IPR043973 CCN, TSP1 domain
      IPR050941 Cellular Communication Network Factor
      IPR006207 Cystine knot, C-terminal
      IPR006208 Glycoprotein hormone subunit beta
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR012395 IGFBP-related, CNN
      IPR000867 Insulin-like growth factor-binding protein, IGFBP
      IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
      IPR001007 VWFC domain
    • GlyGen
      Q64299 2 sites, 4 N-linked glycans (1 site)
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 2
      cDNA 32
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38229, MGI:2443171, MGI:6209566
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 25
      Diseases 1
      Gene Ontology 14
      Phenotypes 26
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:352591 Babey ME, et al., A maternal brain hormone that builds bone. Nature. 2024 Aug;632(8024):357-365
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory