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Trim28 Gene Detail
Summary
  • Symbol
    Trim28
  • Name
    tripartite motif-containing 28
  • Synonyms
    KAP-1, KRIP-1, MommeD9, Tif1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:109274
    NCBI Gene: 21849
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:12758079-12764959 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 7.73 cM, cytoband A2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109274
 protein coding gene Chr7:12733041-12764962 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031662
 protein coding gene Chr7:10432795-10439683 (+)
A/J MGP_AJ_G0031635
 protein coding gene Chr7:10272474-10279338 (+)
AKR/J MGP_AKRJ_G0031558
 protein coding gene Chr7:10499948-10506838 (+)
BALB/cJ MGP_BALBcJ_G0031640
 protein coding gene Chr7:10386955-10393843 (+)
C3H/HeJ MGP_C3HHeJ_G0031362
 protein coding gene Chr7:10606516-10613322 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032104
 protein coding gene Chr7:10962419-10969386 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029198
 protein coding gene Chr7:11870063-11877240 (+)
CAST/EiJ MGP_CASTEiJ_G0030720
 protein coding gene Chr7:8161263-8168132 (+)
CBA/J MGP_CBAJ_G0031319
 protein coding gene Chr7:11182289-11189140 (+)
DBA/2J MGP_DBA2J_G0031477
 protein coding gene Chr7:10154950-10161838 (+)
FVB/NJ MGP_FVBNJ_G0031433
 protein coding gene Chr7:10152735-10159618 (+)
LP/J MGP_LPJ_G0031564
 protein coding gene Chr7:10517319-10524207 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031468
 protein coding gene Chr7:11267887-11274758 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032134
 protein coding gene Chr7:10287710-10294594 (+)
PWK/PhJ MGP_PWKPhJ_G0030448
 protein coding gene Chr7:8638949-8645813 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030274
 protein coding gene Chr7:6399757-6406628 (+)
WSB/EiJ MGP_WSBEiJ_G0030815
 protein coding gene Chr7:10318558-10325438 (+)



Homology
more
  • Human Ortholog
    TRIM28, tripartite motif containing 28
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM28, tripartite motif containing 28
  • Synonyms
    KAP1, PPP1R157, RNF96, TF1B, TIF1B, TIF1beta
  • Links
    NCBI Gene ID: 10155
    neXtProt AC: NX_Q13263
    UniProt: Q13263

  • Chr Location
    19q13.43; chr19:58544064-58550722 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 7 alleles in 9 genetic backgrounds
    2 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted disruption of this gene develop normally until the blastocyst stage and undergo uterine implantation, but become arrested at the early egg-cylinder stage, fail to gastrulate, and are completely resorbed by E8.5. Conditional homozygous KO in ovaries leads to masculinization of follicles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    97
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    985
  • Tissues
    232
  • cDNA Data
    24
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21849 NCBI Gene Model | MGI Sequence Detail 6881 C57BL/6J ±  kb
    transcript NM_011588 RefSeq | MGI Sequence Detail 3255 C57BL/6  
    polypeptide Q62318 UniProt | EBI | MGI Sequence Detail 834 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 24
      Primer pair 4
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-38319, MGI:2138086, MGI:3821594
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 37
      Gene Ontology 29
      Phenotypes 51
    • Earliest
      J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
    • Latest
      J:353425 Xu Y, et al., Heat shock protein gp96 drives natural killer cell maturation and anti-tumor immunity by counteracting Trim28 to stabilize Eomes. Nat Commun. 2024 Feb 6;15(1):1106
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory