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Cd244a Gene Detail
Summary
  • Symbol
    Cd244a
  • Name
    CD244 molecule A
  • Synonyms
    2B4, C9.1, Cd244, F730046O15Rik, Nmrk
  • Feature Type
    protein coding gene
  • IDs
    MGI:109294
    NCBI Gene: 18106
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:171386761-171412884 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.52 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1307 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109294
 protein coding gene Chr1:171386761-171437314 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016766
 protein coding gene Chr1:177388678-177436588 (+)
A/J MGP_AJ_G0016745
 protein coding gene Chr1:170142010-170179971 (+)
AKR/J MGP_AKRJ_G0016711
 protein coding gene Chr1:175280585-175285146 (+)
BALB/cJ MGP_BALBcJ_G0016706
 protein coding gene Chr1:170652393-170694170 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0017168
 protein coding gene Chr1:183259655-183322036 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014875
 protein coding gene Chr1:161765803-161875825 (+)
CAST/EiJ MGP_CASTEiJ_G0016111
 protein coding gene Chr1:175138779-175255006 (+)
CBA/J MGP_CBAJ_G0016504
 protein coding gene Chr1:189809441-189824594 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0016608
 protein coding gene Chr1:167344368-167353486 (+)
LP/J MGP_LPJ_G0016682
 protein coding gene Chr1:178478477-178513874 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016635
 protein coding gene Chr1:197105895-197144721 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017204
 protein coding gene Chr1:175114243-175181762 (+)
PWK/PhJ MGP_PWKPhJ_G0015896
 protein coding gene Chr1:168446195-168460843 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0016172
 protein coding gene Chr1:175263054-175348800 (+)



Homology
more
  • Human Ortholog
    CD244, CD244 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD244, CD244 molecule
  • Synonyms
    2B4, NAIL, NKR2B4, Nmrk, SLAMF4
  • Links
    NCBI Gene ID: 51744
    neXtProt AC: NX_Q9BZW8
    UniProt: Q9BZW8

  • Chr Location
    1q23.3; chr1:160830160-160862887 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CD244 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered natural killer (NK) cell cytolysis. Mice homozygous for an ENU-generated allele exhibit reduced 'missing-self' targets recognition and elimination and increased clearance of B16 melanoma tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    20
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    1
  • cDNA Data
    13
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18106 NCBI Gene Model | MGI Sequence Detail 26124 C57BL/6J ±  kb
transcript NR_187115 RefSeq | MGI Sequence Detail 3833 C57BL/6  
polypeptide Q07763 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 13

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38339, MGI:2442562, MGI:6159378
References
more
  • Summaries
    All 83
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 34
  • Earliest
    J:15522 Mathew PA, et al., Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J Immunol. 1993 Nov 15;151(10):5328-37
  • Latest
    J:350666 Li R, et al., Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48. Cell Rep. 2024 Feb 21;43(3):113800
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory