Ucp2 MGI Mouse Gene Detail - MGI:109354 - uncoupling protein 2 (mitochondrial, proton carrier)

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Ucp2 Gene Detail

Symbol

Ucp2
Name

uncoupling protein 2 (mitochondrial, proton carrier)

Feature Type

protein coding gene
IDs

MGI:109354
NCBI Gene: 22228
Alliance

gene page
Transcription Start Sites

32 TSS

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Sequence Map

Chr7:100142565-100148832 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.36 cM
Mapping Data

6 experiments

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SNPs within 2kb

241 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_109354	protein coding gene	Chr7:100142544-100151227 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032570	protein coding gene	Chr7:103377076-103385742 (+)
A/J	MGP_AJ_G0032544	protein coding gene	Chr7:100776325-100784991 (+)
AKR/J	MGP_AKRJ_G0032480	protein coding gene	Chr7:103175941-103184607 (+)
BALB/cJ	MGP_BALBcJ_G0032555	protein coding gene	Chr7:100452756-100461422 (+)
C3H/HeJ	MGP_C3HHeJ_G0032270	protein coding gene	Chr7:103553933-103562587 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033053	protein coding gene	Chr7:107303753-107312436 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030047	protein coding gene	Chr7:103179180-103188584 (+)
CAST/EiJ	MGP_CASTEiJ_G0031597	protein coding gene	Chr7:95101444-95111120 (+)
CBA/J	MGP_CBAJ_G0032237	protein coding gene	Chr7:110981405-110990094 (+)
DBA/2J	MGP_DBA2J_G0032388	protein coding gene	Chr7:99109641-99118321 (+)
FVB/NJ	MGP_FVBNJ_G0032345	protein coding gene	Chr7:98893763-98902429 (+)
LP/J	MGP_LPJ_G0032478	protein coding gene	Chr7:104729094-104737760 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032378	protein coding gene	Chr7:112412444-112421131 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033075	protein coding gene	Chr7:102441479-102450166 (+)
PWK/PhJ	MGP_PWKPhJ_G0031315	protein coding gene	Chr7:92216738-92227042 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031158	protein coding gene	Chr7:89752042-89760715 (+)
WSB/EiJ	MGP_WSBEiJ_G0031714	protein coding gene	Chr7:103140995-103149678 (+)

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Human Ortholog

UCP2, uncoupling protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UCP2, uncoupling protein 2
Synonyms

BMIQ4, SLC25A8, UCPH
Links

HGNC:12518

NCBI Gene ID: 7351

neXtProt AC: NX_P55851

UniProt: P55851
Chr Location

11q13.4; chr11:73974672-73983202 (-) GRCh38

MGI Vertebrate Homology

Ucp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UCP2
Gene Tree

Ucp2

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Diseases

1 with Ucp2 mouse models; 5 with human UCP2 associations

Human Disease

Mouse Models

Mouse gene associated with disease

polycystic liver disease

IDs

View 1 model

Human gene associated with disease

carotid artery disease

IDs

diabetic neuropathy

IDs

end stage renal disease

IDs

IDs

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

33 phenotypes from 3 alleles in 7 genetic backgrounds
6 phenotypes from multigenic genotypes
115 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

50
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

37
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Ucp2
Incidental Mutations

APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants have elevated pancreatic islet cell ATP levels and increased glucose-stimulated secretion of insulin. Homozygotes also show reduced mitochondrial proton leak in thymocytes and increased resistance to infection by Toxoplasma gondii.

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All GO Annotations

67
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

952
Tissues

149
cDNA Data

19
Literature Summary

28

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ucp2

ZFIN ucp2

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All Sequences

76
RefSeq

12
UniProt

8
CCDS

CCDS21498.1

Ensembl

ENSMUSG00000033685 (Evidence)
NCBI Gene

22228

Representative Sequences				Length	Strain/Species	Flank
	genomic	22228	NCBI Gene Model \| MGI Sequence Detail	6268	C57BL/6J	± kb
	transcript	NR_184451	RefSeq \| MGI Sequence Detail	1739	ZRU/MplStud
	polypeptide	P70406	UniProt \| EBI \| MGI Sequence Detail	309	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000017036 dicarboxylate carrier SLC25A8

(term hierarchy)
PDB

2LCK
InterPro Domains

IPR023395 Mitochondrial carrier domain superfamily

IPR002067 Mitochondrial carrier protein

IPR050391 Mitochondrial Metabolite Transporter

IPR018108 Mitochondrial substrate/solute carrier

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All nucleic 36

Genomic 2

cDNA 22

Primer pair 10

Other 2

Microarray probesets 5

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MGD-MRK-38399

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Summaries

All 235

Developmental Gene Expression 28

Diseases 1

Gene Ontology 16

Phenotypes 115
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345820 Cardarelli S, et al., Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress. Cell Death Dis. 2024 Feb 23;15(2):169

TSS for Ucp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68123	Chr7:100142526-100142531 (+)	-36 bp
Tssr68124	Chr7:100142556-100142577 (+)	2 bp
Tssr68125	Chr7:100142977-100143021 (+)	434 bp
Tssr68126	Chr7:100143036-100143055 (+)	481 bp
Tssr68127	Chr7:100143146-100143162 (+)	589 bp
Tssr68128	Chr7:100143251-100143295 (+)	708 bp
Tssr68129	Chr7:100143476-100143537 (+)	942 bp
Tssr68130	Chr7:100144098-100144103 (+)	1,536 bp
Tssr68131	Chr7:100145194-100145214 (+)	2,639 bp
Tssr68132	Chr7:100145934-100146004 (+)	3,404 bp
Tssr68133	Chr7:100146078-100146102 (+)	3,525 bp
Tssr68134	Chr7:100146306-100146334 (+)	3,755 bp
Tssr68135	Chr7:100147306-100147320 (+)	4,748 bp
Tssr68136	Chr7:100147324-100147349 (+)	4,772 bp
Tssr68137	Chr7:100147358-100147417 (+)	4,823 bp
Tssr68138	Chr7:100147448-100147459 (+)	4,889 bp
Tssr68139	Chr7:100147547-100147568 (+)	4,993 bp
Tssr68140	Chr7:100147569-100147580 (+)	5,010 bp
Tssr68141	Chr7:100147596-100147615 (+)	5,041 bp
Tssr68142	Chr7:100147938-100147950 (+)	5,379 bp
Tssr2342	Chr7:100147955-100147962 (+)	5,394 bp
Tssr68143	Chr7:100147971-100148008 (+)	5,425 bp
Tssr68144	Chr7:100148021-100148034 (+)	5,463 bp
Tssr68145	Chr7:100148035-100148037 (+)	5,471 bp
Tssr68146	Chr7:100148046-100148059 (+)	5,488 bp
Tssr68147	Chr7:100148061-100148083 (+)	5,507 bp
Tssr68148	Chr7:100148093-100148106 (+)	5,535 bp
Tssr68149	Chr7:100148435-100148452 (+)	5,879 bp
Tssr68150	Chr7:100148473-100148490 (+)	5,917 bp
Tssr68151	Chr7:100148505-100148523 (+)	5,949 bp
Tssr68152	Chr7:100148538-100148565 (+)	5,987 bp
Tssr68153	Chr7:100148566-100148588 (+)	6,012 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24