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Rnf103 Gene Detail
Summary
  • Symbol
    Rnf103
  • Name
    ring finger protein 103
  • Synonyms
    kf-1, Zfp103
  • Feature Type
    protein coding gene
  • IDs
    MGI:109483
    NCBI Gene: 22644
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:71470878-71487865 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    402 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109483
 protein coding gene Chr6:71470828-71487865 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030859
 protein coding gene Chr6:71976257-71993251 (+)
A/J MGP_AJ_G0030829
 protein coding gene Chr6:69206652-69223754 (+)
AKR/J MGP_AKRJ_G0030758
 protein coding gene Chr6:71218042-71235317 (+)
BALB/cJ MGP_BALBcJ_G0030840
 protein coding gene Chr6:69240567-69257860 (+)
C3H/HeJ MGP_C3HHeJ_G0030872
 protein coding gene Chr6:113018332-113036729 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031298
 protein coding gene Chr6:73873058-73890829 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028487
 protein coding gene Chr6:68396363-68413531 (+)
CAST/EiJ MGP_CASTEiJ_G0029948
 protein coding gene Chr6:71064394-71081351 (+)
CBA/J MGP_CBAJ_G0030527
 protein coding gene Chr6:76821090-76839710 (+)
DBA/2J MGP_DBA2J_G0030679
 protein coding gene Chr6:68592644-68609630 (+)
FVB/NJ MGP_FVBNJ_G0030632
 protein coding gene Chr6:67950469-67967909 (+)
LP/J MGP_LPJ_G0030758
 protein coding gene Chr6:71902397-71920774 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030667
 protein coding gene Chr6:80310261-80329498 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031324
 protein coding gene Chr6:71041677-71059420 (+)
PWK/PhJ MGP_PWKPhJ_G0029664
 protein coding gene Chr6:67469499-67485938 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029492
 protein coding gene Chr6:69752652-69768467 (+)
WSB/EiJ MGP_WSBEiJ_G0030030
 protein coding gene Chr6:71391431-71408455 (+)



Homology
more
  • Human Ortholog
    RNF103, ring finger protein 103
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF103, ring finger protein 103
  • Synonyms
    HKF-1, KF-1, KF1, ZFP-103, ZFP103
  • Links
    NCBI Gene ID: 7844
    neXtProt AC: NX_O00237
    UniProt: O00237

  • Chr Location
    2p11.2; chr2:86603393-86623877 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display significantly increased anxiety-like behavior under stressful conditions as well as increased prepulse inhibition and a reduced startle amplitude with no detectable changes in exploratory locomotion or behavioral despair.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    48
  • cDNA Data
    42
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052656 Ensembl Gene Model | MGI Sequence Detail 16988 C57BL/6J ±  kb
transcript ENSMUST00000064637 Ensembl | MGI Sequence Detail 3264 Not Applicable  
polypeptide ENSMUSP00000066324 Ensembl | MGI Sequence Detail 683 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 44
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39482, MGI:2141657, MGI:2141666
References
more
  • Summaries
    All 48
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:38480 Yasojima K, et al., Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus. Biochem Biophys Res Commun. 1997 Feb 13;231(2):481-7
  • Latest
    J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory