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Mfng Gene Detail
Summary
  • Symbol
    Mfng
  • Name
    MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  • Synonyms
    manic fringe
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095404
    NCBI Gene: 17305
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78640082-78657675 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    612 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095404
 protein coding gene Chr15:78640082-78657678 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022051
 protein coding gene Chr15:78969735-78988359 (-)
A/J MGP_AJ_G0022012
 protein coding gene Chr15:76259268-76276834 (-)
AKR/J MGP_AKRJ_G0021987
 protein coding gene Chr15:78368346-78385907 (-)
BALB/cJ MGP_BALBcJ_G0022018
 protein coding gene Chr15:76233355-76250907 (-)
C3H/HeJ MGP_C3HHeJ_G0021789
 protein coding gene Chr15:78374367-78393026 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022461
 protein coding gene Chr15:82081983-82101496 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019991
 protein coding gene Chr15:72755095-72773326 (-)
CAST/EiJ MGP_CASTEiJ_G0021310
 protein coding gene Chr15:79062856-79082400 (-)
CBA/J MGP_CBAJ_G0021754
 protein coding gene Chr15:84613824-84631435 (-)
DBA/2J MGP_DBA2J_G0021883
 protein coding gene Chr15:75745860-75763443 (-)
FVB/NJ MGP_FVBNJ_G0021861
 protein coding gene Chr15:74753310-74770867 (-)
LP/J MGP_LPJ_G0021951
 protein coding gene Chr15:79180058-79197614 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021881
 protein coding gene Chr15:89787140-89806111 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022475
 protein coding gene Chr15:78396119-78413770 (-)
PWK/PhJ MGP_PWKPhJ_G0021052
 protein coding gene Chr15:75737776-75759692 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020889
 protein coding gene Chr15:78182082-78199917 (-)
WSB/EiJ MGP_WSBEiJ_G0021362
 protein coding gene Chr15:78759212-78777726 (-)



Homology
more
  • Human Ortholog
    MFNG, MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MFNG, MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  • Links
    NCBI Gene ID: 4242
    neXtProt AC: NX_O00587
    UniProt: O00587

  • Chr Location
    22q13.1; chr22:37469063-37486393 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 5 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation exhibit normal pancreatic development, morphology and physiology. Mice homozygous for a different knock-out allele exhibit altered lymphocyte numbers, abnormal circulating factors II, VII, IX and XI, and decreased prothrombin and partial thromboplastin time.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1040
  • Tissues
    195
  • cDNA Data
    45
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018169 Ensembl Gene Model | MGI Sequence Detail 17594 C57BL/6J ±  kb
    transcript ENSMUST00000018313 Ensembl | MGI Sequence Detail 1865 Not Applicable  
    polypeptide ENSMUSP00000018313 Ensembl | MGI Sequence Detail 321 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 2
      cDNA 46
      Primer pair 3
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146229
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 40
      Diseases 1
      Gene Ontology 11
      Phenotypes 39
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:353339 Butts JC, et al., A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 Aug 19;59(16):2171-2188.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory