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Tuba3b Gene Detail
Summary
  • Symbol
    Tuba3b
  • Name
    tubulin, alpha 3B
  • Synonyms
    M[a]7, Tuba7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095408
    NCBI Gene: 22147
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:145561689-145567203 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 77.62 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095408
 protein coding gene Chr6:145561483-145567205 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031481
 protein coding gene Chr6:150626400-150635036 (+)
A/J MGP_AJ_G0031456
 protein coding gene Chr6:144667510-144673365 (+)
AKR/J MGP_AKRJ_G0031384
 protein coding gene Chr6:148961334-148967076 (+)
BALB/cJ MGP_BALBcJ_G0031463
 protein coding gene Chr6:144420239-144426598 (+)
C3H/HeJ MGP_C3HHeJ_G0031185
 protein coding gene Chr6:149002442-149010532 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031925
 protein coding gene Chr6:154676356-154684729 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029049
 protein coding gene Chr6:143417015-143422835 (+)
CAST/EiJ MGP_CASTEiJ_G0030553
 protein coding gene Chr6:148655982-148661699 (+)
CBA/J MGP_CBAJ_G0031145
 protein coding gene Chr6:160555339-160563121 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0031253
 protein coding gene Chr6:142191567-142197935 (+)
LP/J MGP_LPJ_G0031386
 protein coding gene Chr6:150733501-150740404 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031293
 protein coding gene Chr6:164334098-164342070 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031958
 protein coding gene Chr6:148793178-148800872 (+)
PWK/PhJ MGP_PWKPhJ_G0030280
 protein coding gene Chr6:141963082-141969250 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030104
 protein coding gene Chr6:146956964-146962675 (+)
WSB/EiJ MGP_WSBEiJ_G0030646
 protein coding gene Chr6:149402633-149408408 (+)



Homology
more
  • Human Ortholog
    TUBA3C, tubulin alpha 3c
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBA3C, tubulin alpha 3c
  • Synonyms
    bA408E5.3, TUBA2
  • Links
    NCBI Gene ID: 7278
    neXtProt AC: NX_P0DPH7
    UniProt: P0DPH7

  • Chr Location
    13q12.11; chr13:19173772-19181824 (-)  GRCh38
  • Human Ortholog
    TUBA3D, tubulin alpha 3d
  • Synonyms
    H2-ALPHA, KTCN9, TUBA2
  • Links
    NCBI Gene ID: 113457
    neXtProt AC: NX_P0DPH8
    UniProt: P0DPH8

  • Chr Location
    2q21.1; chr2:131476119-131482934 (+)  GRCh38
  • Human Ortholog
    TUBA3E, tubulin alpha 3e
  • Links
    NCBI Gene ID: 112714
    neXtProt AC: NX_Q6PEY2
    UniProt: Q6PEY2

  • Chr Location
    2q21.1; chr2:130191745-130198439 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TUBA3D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    4 phenotype references
Mice homozygous for a null allele exhibit normal testis size and fertility. Mice homozygous for both Tuba3a and 3b exhibit small testis and postnatal depletion of germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    24
  • cDNA Data
    103
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22147 NCBI Gene Model | MGI Sequence Detail 5515 C57BL/6J ±  kb
    transcript NM_009449 RefSeq | MGI Sequence Detail 1573 Not Specified  
    polypeptide NP_033475 RefSeq | MGI Sequence Detail 450 Not Specified  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 105
      cDNA 103
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 4
    • Earliest
      J:25928 Villasante A, et al., Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Mol Cell Biol. 1986 Jul;6(7):2409-19
    • Latest
      J:308859 Akter MS, et al., CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant genes identifies critical genes for male germ cell development in mice. Sci Rep. 2021 Jul 29;11(1):15438
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory