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Adam10 Gene Detail
Summary
  • Symbol
    Adam10
  • Name
    a disintegrin and metallopeptidase domain 10
  • Synonyms
    1700031C13Rik, kuz, kuzbanian
  • Feature Type
    protein coding gene
  • IDs
    MGI:109548
    NCBI Gene: 11487
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:70586279-70687511 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 39.53 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1553 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109548
 protein coding gene Chr9:70586133-70687511 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035004
 protein coding gene Chr9:70787426-70891590 (+)
A/J MGP_AJ_G0034985
 protein coding gene Chr9:68311556-68414623 (+)
AKR/J MGP_AKRJ_G0034914
 protein coding gene Chr9:69924620-70030293 (+)
BALB/cJ MGP_BALBcJ_G0034977
 protein coding gene Chr9:68026716-68128762 (+)
C3H/HeJ MGP_C3HHeJ_G0034686
 protein coding gene Chr9:70454834-70557936 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035496
 protein coding gene Chr9:72650200-72765979 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032407
 protein coding gene Chr9:67848223-67959247 (+)
CAST/EiJ MGP_CASTEiJ_G0034008
 protein coding gene Chr9:70724712-70831682 (+)
CBA/J MGP_CBAJ_G0034659
 protein coding gene Chr9:75180303-75294742 (+)
DBA/2J MGP_DBA2J_G0034818
 protein coding gene Chr9:68052639-68153971 (+)
FVB/NJ MGP_FVBNJ_G0034760
 protein coding gene Chr9:67375605-67476626 (+)
LP/J MGP_LPJ_G0034899
 protein coding gene Chr9:71016755-71122025 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034801
 protein coding gene Chr9:76253674-76363207 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035518
 protein coding gene Chr9:70079938-70188107 (+)
PWK/PhJ MGP_PWKPhJ_G0033712
 protein coding gene Chr9:68296302-68399247 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033545
 protein coding gene Chr9:70379336-70488320 (+)
WSB/EiJ MGP_WSBEiJ_G0034120
 protein coding gene Chr9:69984457-70089245 (+)



Homology
more
  • Human Ortholog
    ADAM10, ADAM metallopeptidase domain 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM10, ADAM metallopeptidase domain 10
  • Synonyms
    AD10, AD18, CD156c, CDw156, HsT18717, kuz, MADM, RAK
  • Links
    NCBI Gene ID: 102
    neXtProt AC: NX_O14672
    UniProt: O14672

  • Chr Location
    15q21.3; chr15:58588809-58749791 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ADAM10 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    61 phenotypes from 7 alleles in 10 genetic backgrounds
    20 phenotypes from multigenic genotypes
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene leads to embryonic lethality at E9.5. Embryos homozygous for a knock-out allele display decreased size and multiple abnormalities related to Notch signaling, including defects of the developing central nervous system, somites, and cardiovascular system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    123
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    964
  • Tissues
    104
  • cDNA Data
    181
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054693 Ensembl Gene Model | MGI Sequence Detail 101233 C57BL/6J ±  kb
    transcript ENSMUST00000067880 Ensembl | MGI Sequence Detail 4593 Not Applicable  
    polypeptide ENSMUSP00000063839 Ensembl | MGI Sequence Detail 749 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 186
      Genomic 1
      cDNA 181
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-39547, MGI:1914564
    References
    more
    • Summaries
      All 212
      Developmental Gene Expression 29
      Gene Ontology 31
      Phenotypes 81
    • Earliest
      J:45558 Yamazaki K, et al., Assignment of a disintegrin and metalloproteinase domain 10 (Adam10) gene to mouse chromosome 9. Genomics. 1997 Dec 15;46(3):528-9
    • Latest
      J:352196 Rangasamy SB, et al., Treadmill workout activates PPARalpha in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer's disease. Brain Behav Immun. 2023 Jan 19;109:204-218
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory