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Polr2j Gene Detail
Summary
  • Symbol
    Polr2j
  • Name
    polymerase (RNA) II (DNA directed) polypeptide J
  • Synonyms
    14.5kDa, RNA polymerase II subunit RPB14, Rpb11a, Rpo2-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109582
    NCBI Gene: 20022
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136145545-136151801 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.80 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109582
 protein coding gene Chr5:136145485-136151801 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030200
 protein coding gene Chr5:140741801-140748112 (+)
A/J MGP_AJ_G0030168
 protein coding gene Chr5:134682591-134688948 (+)
AKR/J MGP_AKRJ_G0030101
 protein coding gene Chr5:139035491-139041807 (+)
BALB/cJ MGP_BALBcJ_G0030178
 protein coding gene Chr5:136040360-136046732 (+)
C3H/HeJ MGP_C3HHeJ_G0029894
 protein coding gene Chr5:139656382-139662691 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030631
 protein coding gene Chr5:145977216-145983530 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027851
 protein coding gene Chr5:128968250-128974913 (+)
CAST/EiJ MGP_CASTEiJ_G0029304
 protein coding gene Chr5:139055744-139062060 (+)
CBA/J MGP_CBAJ_G0029864
 protein coding gene Chr5:151681980-151688321 (+)
DBA/2J MGP_DBA2J_G0030015
 protein coding gene Chr5:134583199-134589577 (+)
FVB/NJ MGP_FVBNJ_G0029970
 protein coding gene Chr5:133736890-133743100 (+)
LP/J MGP_LPJ_G0030104
 protein coding gene Chr5:141168335-141174751 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030002
 protein coding gene Chr5:154651074-154659476 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030671
 protein coding gene Chr5:138849012-138859316 (+)
PWK/PhJ MGP_PWKPhJ_G0029017
 protein coding gene Chr5:133641923-133648456 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028853
 protein coding gene Chr5:136401624-136407940 (+)
WSB/EiJ MGP_WSBEiJ_G0029377
 protein coding gene Chr5:139575650-139581906 (+)



Homology
more
  • Human Ortholog
    POLR2J, RNA polymerase II subunit J
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR2J, RNA polymerase II subunit J
  • Synonyms
    hRPB14, POLR2J1, RPB11, RPB11A, RPB11m
  • Links
    NCBI Gene ID: 5439
    neXtProt AC: NX_P52435
    UniProt: P52435

  • Chr Location
    7q22.1; chr7:102473128-102478922 (-)  GRCh38
  • Human Ortholog
    POLR2J2, RNA polymerase II subunit J2
  • Synonyms
    HRPB11B, RPB11b1
  • Links
    NCBI Gene ID: 246721
    neXtProt AC: NX_Q9GZM3
    UniProt: Q9GZM3

  • Chr Location
    7q22.1; chr7:102665368-102671663 (-)  GRCh38
  • Human Ortholog
    POLR2J3, RNA polymerase II subunit J3
  • Synonyms
    RPB11b2
  • Links
    NCBI Gene ID: 548644
    neXtProt AC: NX_Q9GZM3
    UniProt: Q9H1A7

  • Chr Location
    7q22.1; chr7:102537918-102572653 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show abnormal morula morphology and complete embryonic lethality before implantation. In vitro, embryos fail to hatch from the zona pellucida and die after 3 days in culture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    103
  • cDNA Data
    76
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20022 NCBI Gene Model | MGI Sequence Detail 6257 C57BL/6J ±  kb
transcript NM_011293 RefSeq | MGI Sequence Detail 586 C57BL/6  
polypeptide O08740 UniProt | EBI | MGI Sequence Detail 117 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000033434 DNA-directed RNA polymerase II subunit RPB11
    (term hierarchy)
  • InterPro Domains
    IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain
    IPR008193 DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site
    IPR022905 DNA-directed RNA polymerase subunit Rpo11-like
    IPR037685 RNA polymerase RBP11
    IPR036603 RNA polymerase, RBP11-like subunit
Molecular
Reagents
less
  • All nucleic 78
    Genomic 2
    cDNA 76

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39581
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:38275 Korobko IV, et al., Protein interaction cloning in yeast of the mouse third largest RNA polymerase II subunit, mRPB31. Gene. 1997 Jan 31;185(1):1-4
  • Latest
    J:282460 Rong Y, et al., ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation. Nucleic Acids Res. 2019 Dec 2;47(21):11387-11402
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory