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Foxi1 Gene Detail
Summary
  • Symbol
    Foxi1
  • Name
    forkhead box I1
  • Synonyms
    Fkh10, Hfh3, HFH-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096329
    NCBI Gene: 14233
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:34154341-34158089 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 19.65 cM, cytoband A5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    209 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096329
 protein coding gene Chr11:34154338-34158089 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018150
 protein coding gene Chr11:32534527-32538278 (-)
A/J MGP_AJ_G0018123
 protein coding gene Chr11:31307229-31310991 (-)
AKR/J MGP_AKRJ_G0018087
 protein coding gene Chr11:32276637-32280395 (-)
BALB/cJ MGP_BALBcJ_G0018092
 protein coding gene Chr11:31485228-31488990 (-)
C3H/HeJ MGP_C3HHeJ_G0017905
 protein coding gene Chr11:32226598-32230360 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018546
 protein coding gene Chr11:33575201-33578952 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016201
 protein coding gene Chr11:29801561-29805225 (-)
CAST/EiJ MGP_CASTEiJ_G0017469
 protein coding gene Chr11:32338097-32341855 (-)
CBA/J MGP_CBAJ_G0017878
 protein coding gene Chr11:35241613-35245371 (-)
DBA/2J MGP_DBA2J_G0017988
 protein coding gene Chr11:31072817-31076579 (-)
FVB/NJ MGP_FVBNJ_G0017982
 protein coding gene Chr11:30903008-30906764 (-)
LP/J MGP_LPJ_G0018060
 protein coding gene Chr11:32803467-32807229 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018006
 protein coding gene Chr11:36136059-36139828 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018585
 protein coding gene Chr11:32434965-32438721 (-)
PWK/PhJ MGP_PWKPhJ_G0017250
 protein coding gene Chr11:31265552-31269406 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017042
 protein coding gene Chr11:32166259-32170051 (-)
WSB/EiJ MGP_WSBEiJ_G0017518
 protein coding gene Chr11:32071747-32075507 (-)



Homology
more
  • Human Ortholog
    FOXI1, forkhead box I1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXI1, forkhead box I1
  • Synonyms
    FKH10, FKHL10, FREAC-6, FREAC6, HFH-3, HFH3
  • Links
    NCBI Gene ID: 2299
    neXtProt AC: NX_Q12951
    UniProt: Q12951

  • Chr Location
    5q35.1; chr5:170105897-170109737 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Foxi1 mouse models; 1 with human FOXI1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 1 allele in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes exhibit 50% perinatal lethality and inner ear defects resulting in vestibular and cochlear dysfunction. They are deaf with signs of impaired balance, and develop renal tubular acidosis in response to a chronic acidic load. Notably, 25% of heterozygotes die at birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1092
  • Tissues
    238
  • cDNA Data
    39
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14233 NCBI Gene Model | MGI Sequence Detail 3749 C57BL/6J ±  kb
    transcript NM_023907 RefSeq | MGI Sequence Detail 2354 ZRU/MplStud  
    polypeptide Q922I5 UniProt | EBI | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 2
      cDNA 40
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16698, MGI:1926069, MGI:99902
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 27
      Diseases 1
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:332093 Szeto IYY, et al., SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2122121119
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory