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Khk Gene Detail
Summary
  • Symbol
    Khk
  • Name
    ketohexokinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096353
    NCBI Gene: 16548
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:31078780-31088592 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 16.90 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    358 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096353
 protein coding gene Chr5:31078775-31088592 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029401
 protein coding gene Chr5:28880228-28890042 (+)
A/J MGP_AJ_G0029367
 protein coding gene Chr5:27943366-27953232 (+)
AKR/J MGP_AKRJ_G0029318
 protein coding gene Chr5:29094930-29104757 (+)
BALB/cJ MGP_BALBcJ_G0029378
 protein coding gene Chr5:28464749-28474568 (+)
C3H/HeJ MGP_C3HHeJ_G0029099
 protein coding gene Chr5:29092922-29102739 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029831
 protein coding gene Chr5:30658012-30667858 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027069
 protein coding gene Chr5:25420916-25431282 (+)
CAST/EiJ MGP_CASTEiJ_G0028510
 protein coding gene Chr5:28186468-28196257 (+)
CBA/J MGP_CBAJ_G0029067
 protein coding gene Chr5:31231810-31241628 (+)
DBA/2J MGP_DBA2J_G0029216
 protein coding gene Chr5:28125221-28135044 (+)
FVB/NJ MGP_FVBNJ_G0029174
 protein coding gene Chr5:27538922-27549059 (+)
LP/J MGP_LPJ_G0029301
 protein coding gene Chr5:29344078-29353900 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029203
 protein coding gene Chr5:32124594-32134446 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029865
 protein coding gene Chr5:28594857-28604674 (+)
PWK/PhJ MGP_PWKPhJ_G0028234
 protein coding gene Chr5:27242980-27252784 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028064
 protein coding gene Chr5:27967691-27977522 (+)
WSB/EiJ MGP_WSBEiJ_G0028590
 protein coding gene Chr5:28660155-28669974 (+)



Homology
more
  • Human Ortholog
    KHK, ketohexokinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KHK, ketohexokinase
  • Synonyms
    FRUCTU
  • Links
    NCBI Gene ID: 3795
    neXtProt AC: NX_P50053
    UniProt: P50053

  • Chr Location
    2p23.3; chr2:27086772-27100762 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KHK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from multigenic genotypes
    59 phenotype references
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    5
  • Gene trapped
    1
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    9
  • Genomic Mutations
    5 involving Khk
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    24 strains or lines available
Mice homozygous for alleles that do not produce isoform A or isoforms A and C exhibit normal fertility, development, blood chemistry, and tissue metabolite levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    122
  • cDNA Data
    144
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16548 NCBI Gene Model | MGI Sequence Detail 9813 C57BL/6J ±  kb
transcript NM_001310524 RefSeq | MGI Sequence Detail 1590 ZRU/MplStud  
polypeptide P97328 UniProt | EBI | MGI Sequence Detail 298 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 146
    cDNA 145
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 92
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 18
    Phenotypes 59
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:338902 Guccini I, et al., Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development. iScience. 2023 Aug 18;26(8):107368
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory