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Psmb10 Gene Detail
Summary
  • Symbol
    Psmb10
  • Name
    proteasome (prosome, macropain) subunit, beta type 10
  • Synonyms
    Mecl-1, Mecl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096380
    NCBI Gene: 19171
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106662360-106665024 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096380
 protein coding gene Chr8:106662360-106665076 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034068
 protein coding gene Chr8:108260887-108263551 (-)
A/J MGP_AJ_G0034049
 protein coding gene Chr8:103933763-103936427 (-)
AKR/J MGP_AKRJ_G0033975
 protein coding gene Chr8:106933493-106936157 (-)
BALB/cJ MGP_BALBcJ_G0034042
 protein coding gene Chr8:104116298-104118962 (-)
C3H/HeJ MGP_C3HHeJ_G0033754
 protein coding gene Chr8:107676297-107678961 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034562
 protein coding gene Chr8:112232507-112235171 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031504
 protein coding gene Chr8:97066482-97069149 (-)
CAST/EiJ MGP_CASTEiJ_G0033080
 protein coding gene Chr8:107195780-107198447 (-)
CBA/J MGP_CBAJ_G0033727
 protein coding gene Chr8:115838083-115840747 (-)
DBA/2J MGP_DBA2J_G0033882
 protein coding gene Chr8:103277007-103279671 (-)
FVB/NJ MGP_FVBNJ_G0033827
 protein coding gene Chr8:102208415-102211079 (-)
LP/J MGP_LPJ_G0033973
 protein coding gene Chr8:108475560-108478224 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033871
 protein coding gene Chr8:119029113-119031777 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034580
 protein coding gene Chr8:106901363-106904027 (-)
PWK/PhJ MGP_PWKPhJ_G0032781
 protein coding gene Chr8:102680881-102683571 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032622
 protein coding gene Chr8:105593409-105596132 (-)
WSB/EiJ MGP_WSBEiJ_G0033196
 protein coding gene Chr8:107587958-107590622 (-)



Homology
more
  • Human Ortholog
    PSMB10, proteasome 20S subunit beta 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMB10, proteasome 20S subunit beta 10
  • Synonyms
    beta2i, IMD121, LMP10, MECL1, PRAAS5
  • Links
    NCBI Gene ID: 5699
    neXtProt AC: NX_P40306
    UniProt: P40306

  • Chr Location
    16q22.1; chr16:67934506-67936864 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PSMB10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice have a reduced number of splenic CD8 T cells with defects in proliferation and an altered T cell receptor repertoire to viral antigens.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    12
  • cDNA Data
    91
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19171 NCBI Gene Model | MGI Sequence Detail 2665 C57BL/6J ±  kb
    transcript NM_013640 RefSeq | MGI Sequence Detail 1270 ZRU/MplStud  
    polypeptide O35955 UniProt | EBI | MGI Sequence Detail 273 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 95
      Genomic 2
      cDNA 91
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 50
    • Earliest
      J:40353 Stohwasser R, et al., Molecular cloning of the mouse proteasome subunits MC14 and MECL-1: reciprocally regulated tissue expression of interferon-gamma-modulated proteasome subunits. Eur J Immunol. 1997 May;27(5):1182-7
    • Latest
      J:326115 Oliveri F, et al., Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation. Front Immunol. 2022;13:870720
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory