Snai2 MGI Mouse Gene Detail - MGI:1096393 - snail family zinc finger 2

Symbol

Snai2
Name

snail family zinc finger 2
Synonyms

Slug, Slugh, Snail2

Feature Type

protein coding gene
IDs

MGI:1096393
NCBI Gene: 20583
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr16:14523716-14527249 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 10.07 cM
Mapping Data

3 experiments

SNPs within 2kb

97 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096393	protein coding gene	Chr16:14523716-14527259 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022548	protein coding gene	Chr16:11800651-11804194 (+)
A/J	MGP_AJ_G0022510	protein coding gene	Chr16:11099197-11102722 (+)
AKR/J	MGP_AKRJ_G0022486	protein coding gene	Chr16:11599333-11602981 (+)
BALB/cJ	MGP_BALBcJ_G0022514	protein coding gene	Chr16:11280229-11283790 (+)
C3H/HeJ	MGP_C3HHeJ_G0022281	protein coding gene	Chr16:11674704-11678253 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022963	protein coding gene	Chr16:11966111-11969654 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020483	protein coding gene	Chr16:11284588-11288112 (+)
CAST/EiJ	MGP_CASTEiJ_G0021808	protein coding gene	Chr16:11705103-11708702 (+)
CBA/J	MGP_CBAJ_G0022250	protein coding gene	Chr16:12472858-12476407 (+)
DBA/2J	MGP_DBA2J_G0022381	protein coding gene	Chr16:11096452-11100001 (+)
FVB/NJ	MGP_FVBNJ_G0022357	protein coding gene	Chr16:11118532-11122067 (+)
LP/J	MGP_LPJ_G0022449	protein coding gene	Chr16:11658320-11661863 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022379	protein coding gene	Chr16:12109697-12113508 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022976	protein coding gene	Chr16:11552689-11556232 (+)
PWK/PhJ	MGP_PWKPhJ_G0021550	protein coding gene	Chr16:11347872-11351527 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021379	protein coding gene	Chr16:11515416-11518965 (+)
WSB/EiJ	MGP_WSBEiJ_G0021856	protein coding gene	Chr16:11574037-11577598 (+)

Human Ortholog

SNAI2, snail family transcriptional repressor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNAI2, snail family transcriptional repressor 2
Synonyms

SLUG, SLUGH, SLUGH1, SNAIL2, WS2D
Links

HGNC:11094

NCBI Gene ID: 6591

neXtProt AC: NX_O43623

UniProt: O43623
Chr Location

8q11.21; chr8:48917598-48921740 (-) GRCh38

MGI Vertebrate Homology

Snai2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SNAI2
Gene Tree

Snai2

Diseases

1 with Snai2 mouse models; 1 with human SNAI2 associations

Human Disease

Mouse Models

Waardenburg syndrome

IDs

View 1 model

piebaldism

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

43 phenotypes from 5 alleles in 6 genetic backgrounds
31 phenotypes from multigenic genotypes
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Targeted

10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations in this gene result in growth retardation and eyelid deformities.

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All GO Annotations

99
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1533
Tissues

409
cDNA Data

35
Literature Summary

114

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SNAI2

Xenbase snai2

ZFIN snai2

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS27974.1

Ensembl

ENSMUSG00000022676 (Evidence)
NCBI Gene

20583

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022676	Ensembl Gene Model \| MGI Sequence Detail	3534	C57BL/6J	± kb
transcript	ENSMUST00000023356	Ensembl \| MGI Sequence Detail	2021	Not Applicable
polypeptide	ENSMUSP00000023356	Ensembl \| MGI Sequence Detail	269	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015309 zinc finger protein SNAI2

(term hierarchy)
InterPro Domains

IPR050527 Snail/Krueppel C2H2-type Zinc-finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 52

Genomic 3

cDNA 35

Primer pair 13

Other 1

Microarray probesets 4

Summaries

All 212

Developmental Gene Expression 114

Diseases 1

Gene Ontology 22

Phenotypes 44
Earliest

J:41071 Savagner P, et al., The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol. 1997 Jun 16;137(6):1403-19
Latest

J:347410 Chen Z, et al., Increased enhancer-promoter interactions during developmental enhancer activation in mammals. Nat Genet. 2024 Apr;56(4):675-685

TSS for Snai2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137208	Chr16:14523439-14523454 (+)	-269 bp
Tssr137209	Chr16:14523459-14523482 (+)	-245 bp
Tssr4799	Chr16:14523483-14523499 (+)	-225 bp
Tssr137210	Chr16:14523517-14523532 (+)	-191 bp
Tssr137211	Chr16:14523696-14523722 (+)	-7 bp
Tssr137212	Chr16:14523732-14523749 (+)	25 bp
Tssr137213	Chr16:14524745-14524767 (+)	1,040 bp
Tssr137214	Chr16:14525979-14525987 (+)	2,267 bp
Tssr137215	Chr16:14526001-14526025 (+)	2,297 bp
Tssr137216	Chr16:14526035-14526045 (+)	2,324 bp
Tssr137217	Chr16:14526074-14526091 (+)	2,367 bp
Tssr137218	Chr16:14526129-14526172 (+)	2,435 bp
Tssr137219	Chr16:14526173-14526198 (+)	2,470 bp
Tssr4800	Chr16:14526200-14526201 (+)	2,485 bp
Tssr137220	Chr16:14526224-14526275 (+)	2,534 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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