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Polr1a Gene Detail
Summary
  • Symbol
    Polr1a
  • Name
    polymerase (RNA) I polypeptide A
  • Synonyms
    194kDa, 2900087K15Rik, 3010014K16Rik, mRPA1, RPA194, Rpo1-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096397
    NCBI Gene: 20019
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:71886037-71956419 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.21 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1993 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096397
 protein coding gene Chr6:71886037-71961919 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030866
 protein coding gene Chr6:72417552-72491837 (+)
A/J MGP_AJ_G0030836
 protein coding gene Chr6:69634832-69708160 (+)
AKR/J MGP_AKRJ_G0030765
 protein coding gene Chr6:71651102-71723096 (+)
BALB/cJ MGP_BALBcJ_G0030847
 protein coding gene Chr6:69658958-69730298 (+)
C3H/HeJ MGP_C3HHeJ_G0030865
 protein coding gene Chr6:112525644-112599655 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031305
 protein coding gene Chr6:74320929-74397193 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028494
 protein coding gene Chr6:68796888-68865711 (+)
CAST/EiJ MGP_CASTEiJ_G0029955
 protein coding gene Chr6:71523883-71596370 (+)
CBA/J MGP_CBAJ_G0030534
 protein coding gene Chr6:77302728-77379389 (+)
DBA/2J MGP_DBA2J_G0030686
 protein coding gene Chr6:69011006-69081151 (+)
FVB/NJ MGP_FVBNJ_G0030639
 protein coding gene Chr6:68395442-68466278 (+)
LP/J MGP_LPJ_G0030765
 protein coding gene Chr6:72336857-72414972 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030674
 protein coding gene Chr6:80764950-80838015 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031331
 protein coding gene Chr6:71473711-71551107 (+)
PWK/PhJ MGP_PWKPhJ_G0029671
 protein coding gene Chr6:67912068-67983058 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029499
 protein coding gene Chr6:70196928-70269354 (+)
WSB/EiJ MGP_WSBEiJ_G0030037
 protein coding gene Chr6:71833269-71904961 (+)



Homology
more
  • Human Ortholog
    POLR1A, RNA polymerase I subunit A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR1A, RNA polymerase I subunit A
  • Synonyms
    A190, AFDCIN, HLD27, RPA1, RPA190, RPA194, RPO1-4, RPO14
  • Links
    NCBI Gene ID: 25885
    neXtProt AC: NX_O95602
    UniProt: O95602

  • Chr Location
    2p11.2; chr2:86020216-86106155 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human POLR1A associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 6 alleles in 6 genetic backgrounds
    22 phenotypes from multigenic genotypes
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit failure of blastocyst formation, increased cell death, and complete embryonic lethality before implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    144
  • cDNA Data
    165
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20019 NCBI Gene Model | MGI Sequence Detail 70383 C57BL/6J ±  kb
    transcript NM_009088 RefSeq | MGI Sequence Detail 6145 ZRU/MplStud  
    polypeptide O35134 UniProt | EBI | MGI Sequence Detail 1717 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      13 Sequences
    • Protein Ontology
      PR:000012982 DNA-directed RNA polymerase I subunit RPA1
      (term hierarchy)
    • EC
      2.7.7.6
    • InterPro Domains
      IPR047107 DNA-directed RNA pol I, largest subunit, C-terminal domain
      IPR015699 DNA-directed RNA pol I, largest subunit, N-terminal domain
      IPR045867 DNA-directed RNA polymerase, subunit beta-prime
      IPR000722 RNA polymerase, alpha subunit
      IPR006592 RNA polymerase, N-terminal
      IPR044893 RNA polymerase Rpb1, clamp domain superfamily
      IPR007080 RNA polymerase Rpb1, domain 1
      IPR007066 RNA polymerase Rpb1, domain 3
      IPR042102 RNA polymerase Rpb1, domain 3 superfamily
      IPR007083 RNA polymerase Rpb1, domain 4
      IPR007081 RNA polymerase Rpb1, domain 5
      IPR038120 RNA polymerase Rpb1, funnel domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 169
      cDNA 168
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1920338, MGI:2441664
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 6
      Gene Ontology 13
      Phenotypes 17
    • Earliest
      J:41855 Seither P, et al., Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I. Mol Gen Genet. 1997 Jun;255(2):180-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory