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Morf4l1 Gene Detail
Summary
  • Symbol
    Morf4l1
  • Name
    mortality factor 4 like 1
  • Synonyms
    MORFRG15, MRG15, TEG-189, Tex189
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096551
    NCBI Gene: 21761
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:89973718-89996827 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 47.42 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    580 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096551
 protein coding gene Chr9:89973718-89996873 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035120
 protein coding gene Chr9:91026116-91051158 (-)
A/J MGP_AJ_G0035101
 protein coding gene Chr9:87881871-87904865 (-)
AKR/J MGP_AKRJ_G0035033
 protein coding gene Chr9:89935180-89966793 (-)
BALB/cJ MGP_BALBcJ_G0035093
 protein coding gene Chr9:87533436-87556500 (-)
C3H/HeJ MGP_C3HHeJ_G0034804
 protein coding gene Chr9:90395138-90423863 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035614
 protein coding gene Chr9:93565227-93591499 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032517
 protein coding gene Chr9:86061985-86085326 (-)
CAST/EiJ MGP_CASTEiJ_G0034116
 protein coding gene Chr9:90175495-90203506 (-)
CBA/J MGP_CBAJ_G0034772
 protein coding gene Chr9:96806977-96835631 (-)
DBA/2J MGP_DBA2J_G0034934
 protein coding gene Chr9:87426177-87450698 (-)
FVB/NJ MGP_FVBNJ_G0034880
 protein coding gene Chr9:86453894-86478324 (-)
LP/J MGP_LPJ_G0035013
 protein coding gene Chr9:91248650-91277165 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034921
 protein coding gene Chr9:98428975-98455898 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035634
 protein coding gene Chr9:90169260-90195313 (-)
PWK/PhJ MGP_PWKPhJ_G0033823
 protein coding gene Chr9:87603695-87628072 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033657
 protein coding gene Chr9:90243498-90272643 (-)
WSB/EiJ MGP_WSBEiJ_G0034236
 protein coding gene Chr9:90053159-90080235 (-)



Homology
more
  • Human Ortholog
    MORF4L1, mortality factor 4 like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MORF4L1, mortality factor 4 like 1
  • Synonyms
    Eaf3, FWP006, HsT17725, MEAF3, MORFRG15, MRG15, S863-6
  • Links
    NCBI Gene ID: 10933
    neXtProt AC: NX_Q9UBU8
    UniProt: Q9UBU8

  • Chr Location
    15q25.1; chr15:78810487-78898139 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display perinatal lethality, cardiac hypertrophy, reduced alveolar space, decreased cell proliferation, congestion of the liver, lung, and spleen, skin edema, and thin skin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    40
  • cDNA Data
    31
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062270 Ensembl Gene Model | MGI Sequence Detail 23110 C57BL/6J ±  kb
    transcript ENSMUST00000085248 Ensembl | MGI Sequence Detail 1882 Not Applicable  
    polypeptide ENSMUSP00000082346 Ensembl | MGI Sequence Detail 362 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 31
      Primer pair 2
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 7
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:35463 Lopez-Fernandez LA, et al., Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. Mamm Genome. 1996 Sep;7(9):698-700
    • Latest
      J:342802 Wang N, et al., Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Neuron. 2022 Oct 19;110(20):3318-3338.e9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory