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Pias2 Gene Detail
Summary
  • Symbol
    Pias2
  • Name
    protein inhibitor of activated STAT 2
  • Synonyms
    6330408K17Rik, ARIP3, Dib, Miz1, PIASxalpha, PIASxb, PIASxbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096566
    NCBI Gene: 17344
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:77152904-77241496 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 52.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1620 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096566
 protein coding gene Chr18:77152883-77243406 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024572
 protein coding gene Chr18:77799325-77892094 (+)
A/J MGP_AJ_G0024539
 protein coding gene Chr18:74392826-74489495 (+)
AKR/J MGP_AKRJ_G0024510
 protein coding gene Chr18:76600209-76690123 (+)
BALB/cJ MGP_BALBcJ_G0024538
 protein coding gene Chr18:74621849-74710172 (+)
C3H/HeJ MGP_C3HHeJ_G0024307
 protein coding gene Chr18:76705999-76798421 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024985
 protein coding gene Chr18:79848523-79942970 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022415
 protein coding gene Chr18:73424670-73509796 (+)
CAST/EiJ MGP_CASTEiJ_G0023779
 protein coding gene Chr18:76970929-77071621 (+)
CBA/J MGP_CBAJ_G0024276
 protein coding gene Chr18:82648559-82761223 (+)
DBA/2J MGP_DBA2J_G0024406
 protein coding gene Chr18:73983499-74074586 (+)
FVB/NJ MGP_FVBNJ_G0024372
 protein coding gene Chr18:73340749-73425629 (+)
LP/J MGP_LPJ_G0024490
 protein coding gene Chr18:77678890-77779979 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024402
 protein coding gene Chr18:83933951-84051654 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025033
 protein coding gene Chr18:76756400-76857429 (+)
PWK/PhJ MGP_PWKPhJ_G0023524
 protein coding gene Chr18:74397497-74488883 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023328
 protein coding gene Chr18:76952528-77045996 (+)
WSB/EiJ MGP_WSBEiJ_G0023843
 protein coding gene Chr18:76722150-76811003 (+)



Homology
more
  • Human Ortholog
    PIAS2, protein inhibitor of activated STAT 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIAS2, protein inhibitor of activated STAT 2
  • Synonyms
    ARIP3, DIP, MIZ1, PIASX, SIZ2, ZMIZ4
  • Links
    NCBI Gene ID: 9063
    neXtProt AC: NX_O75928
    UniProt: O75928

  • Chr Location
    18q21.1; chr18:46803218-46920160 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
An uncharacterized gene trap insertion does not result in an obvious phenotype although abnormalities are reported in the testes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    60
  • cDNA Data
    190
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025423 Ensembl Gene Model | MGI Sequence Detail 88593 C57BL/6J ±  kb
    transcript ENSMUST00000114777 Ensembl | MGI Sequence Detail 3060 Not Applicable  
    polypeptide ENSMUSP00000110425 Ensembl | MGI Sequence Detail 621 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 195
      cDNA 191
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1917978, MGI:2147235, MGI:2147299
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 11
      Gene Ontology 21
      Phenotypes 17
    • Earliest
      J:42027 Wu L, et al., Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA. Mech Dev. 1997 Jul;65(1-2):3-17
    • Latest
      J:350805 Zhang L, et al., Regulation of BCR-mediated Ca(2+) mobilization by MIZ1-TMBIM4 safeguards IgG1(+) GC B cell-positive selection. Sci Immunol. 2024 Apr 5;9(94):eadk0092
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory