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Kng1 Gene Detail
Summary
  • Symbol
    Kng1
  • Name
    kininogen 1
  • Synonyms
    H-kininigen, L-kininogen
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097705
    NCBI Gene: 16644
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:22876970-22900828 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 13.88 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    788 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097705
 protein coding gene Chr16:22876615-22900828 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022677
 protein coding gene Chr16:20606275-20632317 (+)
A/J MGP_AJ_G0022639
 protein coding gene Chr16:19601817-19657886 (+)
AKR/J MGP_AKRJ_G0022613
 protein coding gene Chr16:20455588-20489272 (+)
BALB/cJ MGP_BALBcJ_G0022644
 protein coding gene Chr16:19802126-19841078 (+)
C3H/HeJ MGP_C3HHeJ_G0022408
 protein coding gene Chr16:20548109-20607706 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023093
 protein coding gene Chr16:21076131-21118014 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020611
 protein coding gene Chr16:20260293-20286114 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0022379
 protein coding gene Chr16:21930765-21979774 (+)
DBA/2J MGP_DBA2J_G0022511
 protein coding gene Chr16:19566841-19607793 (+)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0023105
 protein coding gene Chr16:20383022-20423210 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0021507
 protein coding gene Chr16:20126393-20150010 (+)
WSB/EiJ MGP_WSBEiJ_G0021981
 protein coding gene Chr16:20346086-20382708 (+)



Homology
more
  • Human Ortholog
    KNG1, kininogen 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KNG1, kininogen 1
  • Synonyms
    BDK, BK, HAE6, HK, HMWK, KNG
  • Links
    NCBI Gene ID: 3827
    neXtProt AC: NX_P01042
    UniProt: P01042

  • Chr Location
    3q27.3; chr3:186717348-186744410 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KNG1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable and grossly unaffected with normal tail vein bleeding times, despite loss of detectable plasma kininogen. However, homozygotes show a significantly longer time to carotid artery occlusion after RoseBengal and laser-induced arterial injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    205
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16644 NCBI Gene Model | MGI Sequence Detail 23859 C57BL/6J ±  kb
transcript NM_001102411 RefSeq | MGI Sequence Detail 2299 Not Specified  
polypeptide O08677 UniProt | EBI | MGI Sequence Detail 661 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 206
    cDNA 205
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 46
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:46848 Caubin J, et al., Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor. Nucleic Acids Res. 1994 Oct 11;22(20):4132-8
  • Latest
    J:357891 Ohnaka Y, et al., Bradykinin deficiency causes high blood pressure in mice. Biochem Biophys Res Commun. 2023 Nov 12;681:73-79
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory