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Pik3cd Gene Detail
Summary
  • Symbol
    Pik3cd
  • Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  • Synonyms
    2410099E07Rik, 2610208K16Rik, p110delta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098211
    NCBI Gene: 18707
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149733625-149787023 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 80.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    295 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098211
 protein coding gene Chr4:149733625-149787028 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029144
 protein coding gene Chr4:153525714-153601929 (-)
A/J MGP_AJ_G0029109
 protein coding gene Chr4:147111811-147166314 (-)
AKR/J MGP_AKRJ_G0029057
 protein coding gene Chr4:151148073-151208207 (-)
BALB/cJ MGP_BALBcJ_G0029125
 protein coding gene Chr4:147608956-147666264 (-)
C3H/HeJ MGP_C3HHeJ_G0028846
 protein coding gene Chr4:151701749-151755508 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029574
 protein coding gene Chr4:159063838-159131242 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026820
 protein coding gene Chr4:139526842-139582910 (-)
CAST/EiJ MGP_CASTEiJ_G0028259
 protein coding gene Chr4:148941502-148999370 (-)
CBA/J MGP_CBAJ_G0028808
 protein coding gene Chr4:163721452-163781899 (-)
DBA/2J MGP_DBA2J_G0028957
 protein coding gene Chr4:147205040-147261184 (-)
FVB/NJ MGP_FVBNJ_G0028921
 protein coding gene Chr4:146332585-146392521 (-)
LP/J MGP_LPJ_G0029047
 protein coding gene Chr4:153453181-153514691 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028948
 protein coding gene Chr4:166958991-167019127 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029606
 protein coding gene Chr4:151637862-151699078 (-)
PWK/PhJ MGP_PWKPhJ_G0027979
 protein coding gene Chr4:143223303-143279760 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027813
 protein coding gene Chr4:145894466-145952530 (-)
WSB/EiJ MGP_WSBEiJ_G0028339
 protein coding gene Chr4:151792484-151853889 (-)



Homology
more
  • Human Ortholog
    PIK3CD, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3CD, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  • Synonyms
    APDS, IMD14, IMD14A, IMD14B, p110D, P110DELTA, PI3K, ROCHIS
  • Links
    NCBI Gene ID: 5293
    neXtProt AC: NX_O00329
    UniProt: O00329

  • Chr Location
    1p36.22; chr1:9627258-9729114 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human PIK3CD associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 7 alleles in 12 genetic backgrounds
    23 phenotypes from multigenic genotypes
    118 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired B and T cell antigen receptor signaling, reduced or ablated immune responses and decreased immunoglobulin levels. Mutants also develop inflammatory bowel disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    951
  • Tissues
    128
  • cDNA Data
    74
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18707 NCBI Gene Model | MGI Sequence Detail 53399 C57BL/6J ±  kb
    transcript NM_008840 RefSeq | MGI Sequence Detail 5102 C57BL/6  
    polypeptide O35904 UniProt | EBI | MGI Sequence Detail 1043 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      cDNA 74
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1917688, MGI:1925744, MGI:2140589
    References
    more
    • Summaries
      All 186
      Developmental Gene Expression 11
      Gene Ontology 11
      Phenotypes 118
    • Earliest
      J:42042 Chantry D, et al., p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem. 1997 Aug 1;272(31):19236-41
    • Latest
      J:344309 Tzenaki N, et al., A combined opposite targeting of p110delta PI3K and RhoA abrogates skin cancer. Commun Biol. 2024 Jan 5;7(1):26
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory