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Adprh Gene Detail
Summary
  • Symbol
    Adprh
  • Name
    ADP-ribosylarginine hydrolase
  • Synonyms
    Arh1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098234
    NCBI Gene: 11544
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:38265761-38273051 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.86 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    258 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098234
 protein coding gene Chr16:38264392-38273065 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022815
 protein coding gene Chr16:36973891-36981170 (-)
A/J MGP_AJ_G0022780
 protein coding gene Chr16:35137540-35144819 (-)
AKR/J MGP_AKRJ_G0022752
 protein coding gene Chr16:36473762-36481041 (-)
BALB/cJ MGP_BALBcJ_G0022781
 protein coding gene Chr16:35260199-35267478 (-)
C3H/HeJ MGP_C3HHeJ_G0022545
 protein coding gene Chr16:36577017-36584296 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023228
 protein coding gene Chr16:37816013-37823303 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020743
 protein coding gene Chr16:35513857-35521293 (-)
CAST/EiJ MGP_CASTEiJ_G0022071
 protein coding gene Chr16:36732646-36739925 (-)
CBA/J MGP_CBAJ_G0022516
 protein coding gene Chr16:39473387-39480666 (-)
DBA/2J MGP_DBA2J_G0022648
 protein coding gene Chr16:35022901-35030180 (-)
FVB/NJ MGP_FVBNJ_G0022623
 protein coding gene Chr16:35053115-35060394 (-)
LP/J MGP_LPJ_G0022716
 protein coding gene Chr16:36653299-36660578 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022642
 protein coding gene Chr16:38590531-38597810 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023243
 protein coding gene Chr16:36437214-36444493 (-)
PWK/PhJ MGP_PWKPhJ_G0021811
 protein coding gene Chr16:35436650-35443924 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021642
 protein coding gene Chr16:36331557-36338517 (-)
WSB/EiJ MGP_WSBEiJ_G0022115
 protein coding gene Chr16:36507288-36514569 (-)



Homology
more
  • Human Ortholog
    ADPRH, ADP-ribosylarginine hydrolase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADPRH, ADP-ribosylarginine hydrolase
  • Synonyms
    ARH1, hARH1
  • Links
    NCBI Gene ID: 141
    neXtProt AC: NX_P54922
    UniProt: P54922

  • Chr Location
    3q13.33; chr3:119579268-119589945 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased sensitivity to the effects of cholera toxin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    95
  • cDNA Data
    124
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11544 NCBI Gene Model | MGI Sequence Detail 7291 C57BL/6J ±  kb
transcript NM_007414 RefSeq | MGI Sequence Detail 1583 C57BL/6  
polypeptide P54923 UniProt | EBI | MGI Sequence Detail 362 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 124
    cDNA 124

    Microarray probesets 4
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:43393 Takada T, et al., Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase. J Biol Chem. 1993 Aug 25;268(24):17837-43
  • Latest
    J:310399 Ishiwata-Endo H, et al., Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair. JCI Insight. 2018 Nov 15;3(22)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory