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Rgs2 Gene Detail
Summary
  • Symbol
    Rgs2
  • Name
    regulator of G-protein signaling 2
  • Synonyms
    GOS8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098271
    NCBI Gene: 19735
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:143875076-143879887 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 62.56 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098271
 protein coding gene Chr1:143875076-143879899 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016565
 protein coding gene Chr1:148343407-148348218 (-)
A/J MGP_AJ_G0016548
 protein coding gene Chr1:142434214-142439009 (-)
AKR/J MGP_AKRJ_G0016513
 protein coding gene Chr1:146808455-146813250 (-)
BALB/cJ MGP_BALBcJ_G0016508
 protein coding gene Chr1:142864042-142868865 (-)
C3H/HeJ MGP_C3HHeJ_G0016333
 protein coding gene Chr1:146926602-146931397 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016969
 protein coding gene Chr1:153351420-153356243 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014678
 protein coding gene Chr1:135230663-135235452 (-)
CAST/EiJ MGP_CASTEiJ_G0015912
 protein coding gene Chr1:146341335-146346149 (-)
CBA/J MGP_CBAJ_G0016307
 protein coding gene Chr1:158817915-158822710 (-)
DBA/2J MGP_DBA2J_G0016413
 protein coding gene Chr1:141536627-141541452 (-)
FVB/NJ MGP_FVBNJ_G0016411
 protein coding gene Chr1:140024127-140028922 (-)
LP/J MGP_LPJ_G0016484
 protein coding gene Chr1:149372062-149376881 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016437
 protein coding gene Chr1:165230997-165235818 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017005
 protein coding gene Chr1:146542548-146547359 (-)
PWK/PhJ MGP_PWKPhJ_G0015698
 protein coding gene Chr1:140442853-140447646 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015485
 protein coding gene Chr1:145334608-145339427 (-)
WSB/EiJ MGP_WSBEiJ_G0015975
 protein coding gene Chr1:146574471-146579484 (-)



Homology
more
  • Human Ortholog
    RGS2, regulator of G protein signaling 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS2, regulator of G protein signaling 2
  • Synonyms
    G0S8
  • Links
    NCBI Gene ID: 5997
    neXtProt AC: NX_P41220
    UniProt: P41220

  • Chr Location
    1q31.2; chr1:192809039-192812275 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 6 genetic backgrounds
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Heterozygous and homozygous mice for one allele display equivalent levels of blood pressure elevation, renovascular defects, persistent constriction of the resistance vasculature, and prolonged response of the vasculature to vasoconstrictors in vivo. Mice homozygous for another allele appear normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    906
  • Tissues
    98
  • cDNA Data
    14
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19735 NCBI Gene Model | MGI Sequence Detail 4812 C57BL/6J ±  kb
    transcript NM_009061 RefSeq | MGI Sequence Detail 3009 ZRU/MplStud  
    polypeptide O08849 UniProt | EBI | MGI Sequence Detail 211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 2
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 9
      Gene Ontology 14
      Phenotypes 61
    • Earliest
      J:39294 Chen C, et al., Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997 Mar 28;272(13):8679-85
    • Latest
      J:350107 Gumusoglu SB, et al., Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk. Neuropsychopharmacology. 2024 Apr;49(5):864-875
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory