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Per1 Gene Detail
Summary
  • Symbol
    Per1
  • Name
    period circadian clock 1
  • Synonyms
    Hftm, mPer1, m-rigui
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098283
    NCBI Gene: 18626
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:68986043-69000786 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.37 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    346 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098283
 protein coding gene Chr11:68985934-69000791 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018518
 protein coding gene Chr11:69500571-69515302 (+)
A/J MGP_AJ_G0018487
 protein coding gene Chr11:66886706-66901442 (+)
AKR/J MGP_AKRJ_G0018456
 protein coding gene Chr11:68890142-68904881 (+)
BALB/cJ MGP_BALBcJ_G0018458
 protein coding gene Chr11:67208291-67222989 (+)
C3H/HeJ MGP_C3HHeJ_G0018271
 protein coding gene Chr11:68906835-68921564 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018910
 protein coding gene Chr11:71611467-71627165 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016554
 protein coding gene Chr11:63826604-63841218 (+)
CAST/EiJ MGP_CASTEiJ_G0017827
 protein coding gene Chr11:69144086-69158822 (+)
CBA/J MGP_CBAJ_G0018245
 protein coding gene Chr11:74822298-74839849 (+)
DBA/2J MGP_DBA2J_G0018354
 protein coding gene Chr11:66485530-66500177 (+)
FVB/NJ MGP_FVBNJ_G0018344
 protein coding gene Chr11:66107037-66122224 (+)
LP/J MGP_LPJ_G0018425
 protein coding gene Chr11:70087681-70102293 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018367
 protein coding gene Chr11:75449595-75464234 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018951
 protein coding gene Chr11:69135461-69150199 (+)
PWK/PhJ MGP_PWKPhJ_G0017602
 protein coding gene Chr11:67122296-67137117 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017390
 protein coding gene Chr11:68968382-68983146 (+)
WSB/EiJ MGP_WSBEiJ_G0017880
 protein coding gene Chr11:68775491-68790993 (+)



Homology
more
  • Human Ortholog
    PER1, period circadian regulator 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PER1, period circadian regulator 1
  • Synonyms
    hPER, PER, RIGUI
  • Links
    NCBI Gene ID: 5187
    neXtProt AC: NX_O15534
    UniProt: O15534

  • Chr Location
    17p13.1; chr17:8140472-8156506 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Per1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 4 alleles in 8 genetic backgrounds
    13 phenotypes from multigenic genotypes
    131 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display a persistent circadian rhythm, but they have a shorter period and their ability to maintain the precision and the stability of the period is impaired.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    38
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1088
  • Tissues
    158
  • cDNA Data
    64
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020893 Ensembl Gene Model | MGI Sequence Detail 14744 C57BL/6J ±  kb
    transcript ENSMUST00000021271 Ensembl | MGI Sequence Detail 4671 Not Applicable  
    polypeptide ENSMUSP00000021271 Ensembl | MGI Sequence Detail 1291 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      Genomic 1
      cDNA 67
      Primer pair 7
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:3522286
    References
    more
    • Summaries
      All 297
      Developmental Gene Expression 25
      Diseases 1
      Gene Ontology 38
      Phenotypes 131
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:348800 Clark JF, et al., Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development. Genes Dev. 2024 Jun 4;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory