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Rgs5 Gene Detail
Summary
  • Symbol
    Rgs5
  • Name
    regulator of G-protein signaling 5
  • Synonyms
    1110070A02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098434
    NCBI Gene: 19737
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:169483070-169523367 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 76.84 cM, cytoband H2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1314 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098434
 protein coding gene Chr1:169483070-169523382 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016720
 protein coding gene Chr1:175294428-175338648 (+)
A/J MGP_AJ_G0016700
 protein coding gene Chr1:168138537-168179394 (+)
AKR/J MGP_AKRJ_G0016666
 protein coding gene Chr1:173231377-173272107 (+)
BALB/cJ MGP_BALBcJ_G0016661
 protein coding gene Chr1:168645688-168686721 (+)
C3H/HeJ MGP_C3HHeJ_G0016485
 protein coding gene Chr1:173453999-173496678 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017122
 protein coding gene Chr1:181129857-181172328 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014831
 protein coding gene Chr1:159927476-159967461 (+)
CAST/EiJ MGP_CASTEiJ_G0016065
 protein coding gene Chr1:173077627-173119018 (+)
CBA/J MGP_CBAJ_G0016460
 protein coding gene Chr1:187568071-187610607 (+)
DBA/2J MGP_DBA2J_G0016566
 protein coding gene Chr1:167025331-167065700 (+)
FVB/NJ MGP_FVBNJ_G0016564
 protein coding gene Chr1:165410216-165451302 (+)
LP/J MGP_LPJ_G0016637
 protein coding gene Chr1:176357322-176399423 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016589
 protein coding gene Chr1:194883094-194925153 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017159
 protein coding gene Chr1:173101983-173144350 (+)
PWK/PhJ MGP_PWKPhJ_G0015851
 protein coding gene Chr1:166238267-166279119 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015637
 protein coding gene Chr1:171871308-171915633 (+)
WSB/EiJ MGP_WSBEiJ_G0016127
 protein coding gene Chr1:173218926-173259098 (+)



Homology
more
  • Human Ortholog
    RGS5, regulator of G protein signaling 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS5, regulator of G protein signaling 5
  • Synonyms
    MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129
  • Links
    NCBI Gene ID: 8490
    neXtProt AC: NX_O15539
    UniProt: O15539

  • Chr Location
    1q23.3; chr1:163111121-163321791 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human RGS5 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 4 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation appear normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1257
  • Tissues
    264
  • cDNA Data
    128
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19737 NCBI Gene Model | MGI Sequence Detail 40298 C57BL/6J ±  kb
    transcript NM_009063 RefSeq | MGI Sequence Detail 4081 ZRU/MplStud  
    polypeptide O08850 UniProt | EBI | MGI Sequence Detail 181 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 135
      cDNA 128
      Primer pair 5
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1919050
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 31
      Gene Ontology 6
      Phenotypes 33
    • Earliest
      J:39294 Chen C, et al., Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997 Mar 28;272(13):8679-85
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory