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Psmc3 Gene Detail
Summary
  • Symbol
    Psmc3
  • Name
    proteasome (prosome, macropain) 26S subunit, ATPase 3
  • Synonyms
    Tat binding protein 1, TBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098754
    NCBI Gene: 19182
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:90884361-90889783 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098754
 protein coding gene Chr2:90884354-90896714 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026139
 protein coding gene Chr2:92354752-92367105 (+)
A/J MGP_AJ_G0026100
 protein coding gene Chr2:88661309-88673665 (+)
AKR/J MGP_AKRJ_G0026081
 protein coding gene Chr2:91114854-91127208 (+)
BALB/cJ MGP_BALBcJ_G0026109
 protein coding gene Chr2:88826396-88838756 (+)
C3H/HeJ MGP_C3HHeJ_G0025860
 protein coding gene Chr2:91389999-91403423 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026560
 protein coding gene Chr2:95612224-95624582 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023951
 protein coding gene Chr2:85179029-85191466 (+)
CAST/EiJ MGP_CASTEiJ_G0025325
 protein coding gene Chr2:91912990-91927174 (+)
CBA/J MGP_CBAJ_G0025838
 protein coding gene Chr2:98856148-98873144 (+)
DBA/2J MGP_DBA2J_G0025974
 protein coding gene Chr2:88259985-88272345 (+)
FVB/NJ MGP_FVBNJ_G0025937
 protein coding gene Chr2:87366479-87378835 (+)
LP/J MGP_LPJ_G0026078
 protein coding gene Chr2:92561842-92574202 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025963
 protein coding gene Chr2:101902407-101914767 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026614
 protein coding gene Chr2:91172996-91185356 (+)
PWK/PhJ MGP_PWKPhJ_G0025060
 protein coding gene Chr2:87988609-88001051 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024861
 protein coding gene Chr2:90755189-90767739 (+)
WSB/EiJ MGP_WSBEiJ_G0025392
 protein coding gene Chr2:91765154-91777511 (+)



Homology
more
  • Human Ortholog
    PSMC3, proteasome 26S subunit, ATPase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMC3, proteasome 26S subunit, ATPase 3
  • Synonyms
    DCIDP, RPT5, TBP1
  • Links
    NCBI Gene ID: 5702
    neXtProt AC: NX_P17980
    UniProt: P17980

  • Chr Location
    11p11.2; chr11:47418769-47426473 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    111
  • cDNA Data
    314
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19182 NCBI Gene Model | MGI Sequence Detail 5423 C57BL/6J ±  kb
transcript NM_008948 RefSeq | MGI Sequence Detail 1651 ZRU/MplStud  
polypeptide O88685 UniProt | EBI | MGI Sequence Detail 442 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 315
    cDNA 314
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory