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Pik3r2 Gene Detail
Summary
  • Symbol
    Pik3r2
  • Name
    phosphoinositide-3-kinase regulatory subunit 2
  • Synonyms
    p85beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098772
    NCBI Gene: 18709
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71220820-71229356 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098772
 protein coding gene Chr8:71220820-71229357 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033726
 protein coding gene Chr8:71069123-71079813 (-)
A/J MGP_AJ_G0033709
 protein coding gene Chr8:68172830-68181367 (-)
AKR/J MGP_AKRJ_G0033634
 protein coding gene Chr8:70129934-70138521 (-)
BALB/cJ MGP_BALBcJ_G0033705
 protein coding gene Chr8:68408676-68417306 (-)
C3H/HeJ MGP_C3HHeJ_G0033415
 protein coding gene Chr8:70773554-70782177 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034222
 protein coding gene Chr8:73748529-73757063 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031166
 protein coding gene Chr8:62990622-62999291 (-)
CAST/EiJ MGP_CASTEiJ_G0032740
 protein coding gene Chr8:70246909-70255872 (-)
CBA/J MGP_CBAJ_G0033393
 protein coding gene Chr8:76413609-76422164 (-)
DBA/2J MGP_DBA2J_G0033547
 protein coding gene Chr8:67891605-67900592 (-)
FVB/NJ MGP_FVBNJ_G0033488
 protein coding gene Chr8:67029108-67038412 (-)
LP/J MGP_LPJ_G0033634
 protein coding gene Chr8:71090166-71099515 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033531
 protein coding gene Chr8:79042244-79052351 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034240
 protein coding gene Chr8:70306880-70317938 (-)
PWK/PhJ MGP_PWKPhJ_G0032448
 protein coding gene Chr8:67188962-67197582 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032284
 protein coding gene Chr8:69273548-69282088 (-)
WSB/EiJ MGP_WSBEiJ_G0032855
 protein coding gene Chr8:70674201-70682799 (-)



Homology
more
  • Human Ortholog
    PIK3R2, phosphoinositide-3-kinase regulatory subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3R2, phosphoinositide-3-kinase regulatory subunit 2
  • Synonyms
    MPPH, MPPH1, p85, P85B, p85beta, p85-BETA
  • Links
    NCBI Gene ID: 5296
    neXtProt AC: NX_O00459
    UniProt: O00459

  • Chr Location
    19p13.11; chr19:18153163-18170532 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PIK3R2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have lower blood glucose levels both when fed and after fasting. Insulin sensitivity is improved as well. Homozygosity for the p.G367R mutation leads to enlarged brains and brain ventricles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    863
  • Tissues
    115
  • cDNA Data
    78
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18709 NCBI Gene Model | MGI Sequence Detail 8537 C57BL/6J ±  kb
    transcript NM_001424805 RefSeq | MGI Sequence Detail 3286 C57BL/6  
    polypeptide O08908 UniProt | EBI | MGI Sequence Detail 722 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 78
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 37
    • Earliest
      J:36742 Pons S, et al., The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol. 1995 Aug;15(8):4453-65
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory