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Tbrg4 Gene Detail
Summary
  • Symbol
    Tbrg4
  • Name
    transforming growth factor beta regulated gene 4
  • Synonyms
    2310042P22Rik, Cpr2, mKIAA0948, TB-12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100868
    NCBI Gene: 21379
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:6565598-6576067 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 4.60 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100868
 protein coding gene Chr11:6565598-6576089 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018028
 protein coding gene Chr11:3764370-3776008 (-)
A/J MGP_AJ_G0018001
 protein coding gene Chr11:3594603-3605034 (-)
AKR/J MGP_AKRJ_G0017965
 protein coding gene Chr11:3769752-3780882 (-)
BALB/cJ MGP_BALBcJ_G0017969
 protein coding gene Chr11:3602508-3612976 (-)
C3H/HeJ MGP_C3HHeJ_G0017782
 protein coding gene Chr11:3660440-3670879 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018421
 protein coding gene Chr11:3857644-3868206 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016079
 protein coding gene Chr11:3476648-3487137 (-)
CAST/EiJ MGP_CASTEiJ_G0017344
 protein coding gene Chr11:3647223-3659044 (-)
CBA/J MGP_CBAJ_G0017757
 protein coding gene Chr11:4289859-4300479 (-)
DBA/2J MGP_DBA2J_G0017867
 protein coding gene Chr11:3503844-3514305 (-)
FVB/NJ MGP_FVBNJ_G0017859
 protein coding gene Chr11:3527847-3541350 (-)
LP/J MGP_LPJ_G0017938
 protein coding gene Chr11:3826320-3837703 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017885
 protein coding gene Chr11:3833860-3848922 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018461
 protein coding gene Chr11:3800353-3812218 (-)
PWK/PhJ MGP_PWKPhJ_G0017124
 protein coding gene Chr11:3542181-3552937 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016921
 protein coding gene Chr11:3747095-3757628 (-)
WSB/EiJ MGP_WSBEiJ_G0017398
 protein coding gene Chr11:3630423-3640796 (-)



Homology
more
  • Human Ortholog
    TBRG4, transforming growth factor beta regulator 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBRG4, transforming growth factor beta regulator 4
  • Synonyms
    CPR2, FASTKD4
  • Links
    NCBI Gene ID: 9238
    neXtProt AC: NX_Q969Z0
    UniProt: Q969Z0

  • Chr Location
    7p13; chr7:45100100-45112047 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    7
  • cDNA Data
    18
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000384 Ensembl Gene Model | MGI Sequence Detail 10470 C57BL/6J ±  kb
transcript ENSMUST00000189268 Ensembl | MGI Sequence Detail 2347 Not Applicable  
polypeptide ENSMUSP00000140835 Ensembl | MGI Sequence Detail 630 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 1
    cDNA 18

    Microarray probesets 8
Other
Accession IDs
less
MGI:1922070, MGI:1927639, MGI:2143975, MGI:2144216, MGI:2144699, MGI:3527256
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:26127 Babalola GO, et al., Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta. Mol Reprod Dev. 1995 Jun;41(2):133-9
  • Latest
    J:309442 Mayere C, et al., Single-cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination. FASEB J. 2021 Apr;35(4):e21452
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory