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Tnfrsf9 Gene Detail
Summary
  • Symbol
    Tnfrsf9
  • Name
    tumor necrosis factor receptor superfamily, member 9
  • Synonyms
    4-1BB, A930040I11Rik, Cd137, CDw137, ILA, Ly63
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101059
    NCBI Gene: 21942
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:151004612-151030561 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 81.52 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101059
 protein coding gene Chr4:150999019-151030561 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029158
 protein coding gene Chr4:154942357-154975022 (+)
A/J MGP_AJ_G0029123
 protein coding gene Chr4:148421498-148454100 (+)
AKR/J MGP_AKRJ_G0029071
 protein coding gene Chr4:152488833-152522987 (+)
BALB/cJ MGP_BALBcJ_G0029139
 protein coding gene Chr4:148917731-148951622 (+)
C3H/HeJ MGP_C3HHeJ_G0028860
 protein coding gene Chr4:153052719-153088869 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029588
 protein coding gene Chr4:160503569-160539038 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026834
 protein coding gene Chr4:140812161-140844128 (+)
CAST/EiJ MGP_CASTEiJ_G0028273
 protein coding gene Chr4:150330802-150368918 (+)
CBA/J MGP_CBAJ_G0028822
 protein coding gene Chr4:165267299-165302445 (+)
DBA/2J MGP_DBA2J_G0028971
 protein coding gene Chr4:148502052-148533471 (+)
FVB/NJ MGP_FVBNJ_G0028935
 protein coding gene Chr4:147647268-147679016 (+)
LP/J MGP_LPJ_G0029061
 protein coding gene Chr4:154869358-154904276 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028962
 protein coding gene Chr4:168386227-168421597 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029620
 protein coding gene Chr4:153014100-153048942 (+)
PWK/PhJ MGP_PWKPhJ_G0027993
 protein coding gene Chr4:144540259-144572474 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027827
 protein coding gene Chr4:147258096-147302307 (+)
WSB/EiJ MGP_WSBEiJ_G0028353
 protein coding gene Chr4:153152125-153184396 (+)



Homology
more
  • Human Ortholog
    TNFRSF9, TNF receptor superfamily member 9
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF9, TNF receptor superfamily member 9
  • Synonyms
    4-1BB, CD137, CDw137, ILA, IMD109
  • Links
    NCBI Gene ID: 3604
    neXtProt AC: NX_Q07011
    UniProt: Q07011

  • Chr Location
    1p36.23; chr1:7915871-7943165 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TNFRSF9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 6 alleles in 7 genetic backgrounds
    29 phenotypes from multigenic genotypes
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in enhanced T cell proliferation, decreased B cell IgG production, decreased cytotoxic T cell activity, and increased numbers of erythrocytes, granulocyte macrophages, and multipotential progenitor cells in the bone marrow, blood, and spleen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    48
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21942 NCBI Gene Model | MGI Sequence Detail 25950 C57BL/6J ±  kb
    transcript NM_011612 RefSeq | MGI Sequence Detail 2134 ZRU/MplStud  
    polypeptide P20334 UniProt | EBI | MGI Sequence Detail 256 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 1
      cDNA 52

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1925690, MGI:2140130, MGI:2140239
    References
    more
    • Summaries
      All 182
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 7
      Phenotypes 83
    • Earliest
      J:14661 Kwon BS, et al., cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci U S A. 1989 Mar;86(6):1963-7
    • Latest
      J:350954 Ziblat A, et al., Batf3(+) DCs and the 4-1BB/4-1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy. Cell Rep. 2024 May 28;43(5):114141
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory