Ttk MGI Mouse Gene Detail - MGI:1194921

Symbol

Ttk
Name

Ttk protein kinase
Synonyms

Esk1, Mps1

Feature Type

protein coding gene
IDs

MGI:1194921
NCBI Gene: 22137
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr9:83716742-83754442 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 45.61 cM
Mapping Data

2 experiments

SNPs within 2kb

1133 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1194921	protein coding gene	Chr9:83716704-83754442 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035089	protein coding gene	Chr9:84527665-84566982 (+)
A/J	MGP_AJ_G0035070	protein coding gene	Chr9:81596846-81634506 (+)
AKR/J	MGP_AKRJ_G0034998	protein coding gene	Chr9:83508225-83550141 (+)
BALB/cJ	MGP_BALBcJ_G0035058	protein coding gene	Chr9:81258725-81296530 (+)
C3H/HeJ	MGP_C3HHeJ_G0034770	protein coding gene	Chr9:84037507-84075560 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035581	protein coding gene	Chr9:86844294-86881798 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032489	protein coding gene	Chr9:80508997-80546112 (+)
CAST/EiJ	MGP_CASTEiJ_G0034088	protein coding gene	Chr9:84441352-84481885 (+)
CBA/J	MGP_CBAJ_G0034743	protein coding gene	Chr9:89951648-89995662 (+)
DBA/2J	MGP_DBA2J_G0034901	protein coding gene	Chr9:81186459-81226110 (+)
FVB/NJ	MGP_FVBNJ_G0034844	protein coding gene	Chr9:80315445-80354967 (+)
LP/J	MGP_LPJ_G0034982	protein coding gene	Chr9:84735355-84776302 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034886	protein coding gene	Chr9:91366524-91409922 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035602	protein coding gene	Chr9:83688810-83730776 (+)
PWK/PhJ	MGP_PWKPhJ_G0033792	protein coding gene	Chr9:81346125-81388319 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033628	protein coding gene	Chr9:83833390-83870871 (+)
WSB/EiJ	MGP_WSBEiJ_G0034205	protein coding gene	Chr9:83678748-83718012 (+)

Human Ortholog

TTK, TTK protein kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TTK, TTK protein kinase
Synonyms

CT96, ESK, MPH1, MPS1, MPS1L1, PYT
Links

HGNC:12401

NCBI Gene ID: 7272

neXtProt AC: NX_P33981

UniProt: P33981
Chr Location

6q14.1; chr6:80003887-80042527 (+) GRCh38

MGI Vertebrate Homology

Ttk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TTK
Gene Tree

Ttk

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

16
Targeted

5
Genomic Mutations

1 involving Ttk
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. Mice homozygous for a floxed allele activated in oocytes exhibit reduced female fertility associated with defective spindle assembly checkpoint, premature chromosome segregation, and accelerated anaphase and polar body extrusion.

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All GO Annotations

35
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

10
cDNA Data

70
Literature Summary

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ttk

ZFIN ttk

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All Sequences

60
RefSeq

10
UniProt

6
CCDS

CCDS52874.1, CCDS81044.1

Ensembl

ENSMUSG00000038379 (Evidence)
NCBI Gene

22137

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038379	Ensembl Gene Model \| MGI Sequence Detail	37701	C57BL/6J	± kb
transcript	ENSMUST00000070326	Ensembl \| MGI Sequence Detail	2871	Not Applicable
polypeptide	ENSMUSP00000064839	Ensembl \| MGI Sequence Detail	830	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000016787 dual specificity protein kinase TTK

(term hierarchy)
EC

2.7.12.1
InterPro Domains

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR027084 Protein kinase Mps1 family, catalytic domain

IPR008271 Serine/threonine-protein kinase, active site

IPR011990 Tetratricopeptide-like helical domain superfamily

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All nucleic 73

cDNA 70

Primer pair 2

Other 1

Microarray probesets 4

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MGI:2143170

Summaries

All 57

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 21
Earliest

J:43402 Douville EM, et al., Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms. Mol Cell Biol. 1992 Jun;12(6):2681-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ttk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86358	Chr9:83716698-83716721 (+)	-32 bp
Tssr86359	Chr9:83716737-83716789 (+)	21 bp
Tssr86360	Chr9:83725185-83725196 (+)	8,449 bp
Tssr86361	Chr9:83748614-83748623 (+)	31,877 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24