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Ilk Gene Detail
Summary
  • Symbol
    Ilk
  • Name
    integrin linked kinase
  • Synonyms
    ESTM24
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195267
    NCBI Gene: 16202
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:105385799-105392132 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.97 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195267
 protein coding gene Chr7:105385797-105392132 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032762
 protein coding gene Chr7:109005881-109012201 (+)
A/J MGP_AJ_G0032742
 protein coding gene Chr7:106156539-106162865 (+)
AKR/J MGP_AKRJ_G0032675
 protein coding gene Chr7:108923199-108929485 (+)
BALB/cJ MGP_BALBcJ_G0032748
 protein coding gene Chr7:105865061-105871386 (+)
C3H/HeJ MGP_C3HHeJ_G0032457
 protein coding gene Chr7:109030696-109037011 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033253
 protein coding gene Chr7:113366328-113372664 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030237
 protein coding gene Chr7:108123761-108130135 (+)
CAST/EiJ MGP_CASTEiJ_G0031787
 protein coding gene Chr7:100856600-100866966 (+)
CBA/J MGP_CBAJ_G0032431
 protein coding gene Chr7:117139031-117145362 (+)
DBA/2J MGP_DBA2J_G0032584
 protein coding gene Chr7:104416722-104423043 (+)
FVB/NJ MGP_FVBNJ_G0032537
 protein coding gene Chr7:104224659-104230994 (+)
LP/J MGP_LPJ_G0032675
 protein coding gene Chr7:110411994-110418314 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032569
 protein coding gene Chr7:118716237-118722520 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033274
 protein coding gene Chr7:107993999-108002308 (+)
PWK/PhJ MGP_PWKPhJ_G0031500
 protein coding gene Chr7:97357728-97364232 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031349
 protein coding gene Chr7:95103996-95110337 (+)
WSB/EiJ MGP_WSBEiJ_G0031904
 protein coding gene Chr7:108631346-108637661 (+)



Homology
more
  • Human Ortholog
    ILK, integrin linked kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ILK, integrin linked kinase
  • Synonyms
    HEL-S-28, ILK-1, ILK-2, P59, p59ILK
  • Links
    NCBI Gene ID: 3611
    neXtProt AC: NX_Q13418
    UniProt: Q13418

  • Chr Location
    11p15.4; chr11:6603708-6610874 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ilk mouse models; 1 with human ILK associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    96 phenotypes from 6 alleles in 9 genetic backgrounds
    23 phenotypes from multigenic genotypes
    1 images
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous embryos do not polarize the epiblast and die after implantation. Mice with mutations in the ATP-binding site show aphagia, hunched posture, and neonatal death due to renal aplasia. Mice with mutations in the paxillin-binding site show vasculogenesis and growth defects, and die at ~E12.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    116
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    91
  • cDNA Data
    9
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030890 Ensembl Gene Model | MGI Sequence Detail 6334 C57BL/6J ±  kb
    transcript ENSMUST00000033182 Ensembl | MGI Sequence Detail 1795 Not Applicable  
    polypeptide ENSMUSP00000033182 Ensembl | MGI Sequence Detail 452 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000009009 integrin-linked protein kinase
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR050776 Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR035692 Integrin-linked protein kinase, pseudokinase domain
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050167 Serine/threonine-protein kinase
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    • GlyGen
      O55222 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 12
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1201384
    References
    more
    • Summaries
      All 186
      Developmental Gene Expression 36
      Diseases 1
      Gene Ontology 26
      Phenotypes 104
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:348349 Campillo S, et al., Integrin-linked kinase mRNA expression in circulating mononuclear cells as a biomarker of kidney and vascular damage in experimental chronic kidney disease. Cell Commun Signal. 2024 May 11;22(1):264
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory