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Sigmar1 Gene Detail
Summary
  • Symbol
    Sigmar1
  • Name
    sigma non-opioid intracellular receptor 1
  • Synonyms
    mSigmaR1, Oprs1, Sig1R
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195268
    NCBI Gene: 18391
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:41738493-41741359 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 22.05 cM, cytoband A5-B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195268
 protein coding gene Chr4:41738493-41756157 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028171
 protein coding gene Chr4:39704427-39723041 (-)
A/J MGP_AJ_G0028129
 protein coding gene Chr4:38194916-38212610 (-)
AKR/J MGP_AKRJ_G0028092
 protein coding gene Chr4:39183468-39204722 (-)
BALB/cJ MGP_BALBcJ_G0028142
 protein coding gene Chr4:38537712-38555283 (-)
C3H/HeJ MGP_C3HHeJ_G0027880
 protein coding gene Chr4:39776812-39794405 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028583
 protein coding gene Chr4:41201129-41218818 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0027325
 protein coding gene Chr4:39421515-39439227 (-)
CBA/J MGP_CBAJ_G0027842
 protein coding gene Chr4:42570712-42590898 (-)
DBA/2J MGP_DBA2J_G0027986
 protein coding gene Chr4:38122483-38140580 (-)
FVB/NJ MGP_FVBNJ_G0027953
 protein coding gene Chr4:37442066-37460927 (-)
LP/J MGP_LPJ_G0028094
 protein coding gene Chr4:39795188-39813794 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027985
 protein coding gene Chr4:45884250-45902982 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028641
 protein coding gene Chr4:39296519-39315405 (-)
PWK/PhJ MGP_PWKPhJ_G0027044
 protein coding gene Chr4:38163884-38181659 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026871
 protein coding gene Chr4:39026901-39046849 (-)
WSB/EiJ MGP_WSBEiJ_G0027401
 protein coding gene Chr4:39280660-39299071 (-)



Homology
more
  • Human Ortholog
    SIGMAR1, sigma non-opioid intracellular receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIGMAR1, sigma non-opioid intracellular receptor 1
  • Synonyms
    ALS16, DSMA2, HMNR2, hSigmaR1, OPRS1, SIG-1R, sigma1R, SR-BP, SRBP, SR-BP1
  • Links
    NCBI Gene ID: 10280
    neXtProt AC: NX_Q99720
    UniProt: Q99720

  • Chr Location
    9p13.3
Human Diseases
more
  • Diseases
    2 with human SIGMAR1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit abnormal motor coordination and increased depressive-like behavior. Mice homozygous for a knock-out allele exhibit reduced sponataneous activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    49
  • cDNA Data
    92
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18391 NCBI Gene Model | MGI Sequence Detail 2867 C57BL/6J ±  kb
transcript NM_011014 RefSeq | MGI Sequence Detail 1640 C57BL/6  
polypeptide O55242 UniProt | EBI | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 94
    Genomic 2
    cDNA 92

    Microarray probesets 6
Other
Accession IDs
less
MGI:2140414
References
more
  • Summaries
    All 145
    Developmental Gene Expression 6
    Gene Ontology 14
    Phenotypes 85
  • Earliest
    J:44925 Seth P, et al., Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor. Biochem Biophys Res Commun. 1997 Dec 18;241(2):535-40
  • Latest
    J:348365 Remex NS, et al., Deletion of Sigmar1 leads to increased arterial stiffness and altered mitochondrial respiration resulting in vascular dysfunction. Front Physiol. 2024;15:1386296
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory