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Angel2 Gene Detail
Summary
  • Symbol
    Angel2
  • Name
    angel homolog 2
  • Synonyms
    2610307I21Rik, 5730410O10Rik, D1Ertd396e, D1Ertd654e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196310
    NCBI Gene: 52477
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:190657309-190679159 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 96.28 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    547 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196310
 protein coding gene Chr1:190657305-190679160 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016933
 protein coding gene Chr1:197935050-197957404 (+)
A/J MGP_AJ_G0016912
 protein coding gene Chr1:189828108-189849944 (+)
AKR/J MGP_AKRJ_G0016877
 protein coding gene Chr1:195439202-195461030 (+)
BALB/cJ MGP_BALBcJ_G0016870
 protein coding gene Chr1:190504055-190525879 (+)
C3H/HeJ MGP_C3HHeJ_G0016694
 protein coding gene Chr1:196295475-196318059 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017333
 protein coding gene Chr1:204244543-204266879 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015040
 protein coding gene Chr1:180734183-180755796 (+)
CAST/EiJ MGP_CASTEiJ_G0016277
 protein coding gene Chr1:195885087-195907495 (+)
CBA/J MGP_CBAJ_G0016668
 protein coding gene Chr1:211806016-211830411 (+)
DBA/2J MGP_DBA2J_G0016774
 protein coding gene Chr1:188551251-188573204 (+)
FVB/NJ MGP_FVBNJ_G0016770
 protein coding gene Chr1:186676518-186698589 (+)
LP/J MGP_LPJ_G0016849
 protein coding gene Chr1:199110765-199133074 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016802
 protein coding gene Chr1:218523574-218546411 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017370
 protein coding gene Chr1:195328177-195353646 (+)
PWK/PhJ MGP_PWKPhJ_G0016064
 protein coding gene Chr1:187827175-187849479 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015840
 protein coding gene Chr1:194317079-194339762 (+)
WSB/EiJ MGP_WSBEiJ_G0016339
 protein coding gene Chr1:195549875-195571601 (+)



Homology
more
  • Human Ortholog
    ANGEL2, angel homolog 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANGEL2, angel homolog 2
  • Synonyms
    Ccr4d, KIAA0759L
  • Links
    NCBI Gene ID: 90806
    neXtProt AC: NX_Q5VTE6
    UniProt: Q5VTE6

  • Chr Location
    1q32.3; chr1:212992182-213015867 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and overtly normal but show a mild alteration of de novo translation in heart and liver mitochondria. Mitochondrial transcripts that undergo non-canonical RNA processing accumulate 3' phosphates, preventing their polyadenylation, causing a respiratory chain deficiency.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    148
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026634 Ensembl Gene Model | MGI Sequence Detail 21851 C57BL/6J ±  kb
transcript ENSMUST00000066632 Ensembl | MGI Sequence Detail 3714 Not Applicable  
polypeptide ENSMUSP00000064556 Ensembl | MGI Sequence Detail 544 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004022 protein angel homolog 2
    (term hierarchy)
  • InterPro Domains
    IPR050410 CCR4/nocturin mRNA turnover and transcription
    IPR005135 Endonuclease/exonuclease/phosphatase
    IPR036691 Endonuclease/exonuclease/phosphatase superfamily
    IPR045816 Protein angel homolog 2, N-terminal
  • GlyGen
    Q8K1C0 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 152
    cDNA 150
    Primer pair 2

    Microarray probesets 10
Other
Accession IDs
less
MGI:1277170, MGI:1917712, MGI:1917755, MGI:2138341
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:51600 Fowler KJ, et al., Mouse centromere protein F (Cenpf) gene maps to the distal region of chromosome 1 by interspecific backcross analysis. Cytogenet Cell Genet. 1998;82(3-4):180-1
  • Latest
    J:332461 Clemente P, et al., ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing. Nat Commun. 2022 Sep 30;13(1):5750
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory