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Hyal2 Gene Detail
Summary
  • Symbol
    Hyal2
  • Name
    hyaluronoglucosaminidase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196334
    NCBI Gene: 15587
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107445144-107449978 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 58.12 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    176 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196334
 protein coding gene Chr9:107445096-107449978 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035259
 protein coding gene Chr9:109443363-109448192 (+)
A/J MGP_AJ_G0035238
 protein coding gene Chr9:105464911-105469740 (+)
AKR/J MGP_AKRJ_G0035170
 protein coding gene Chr9:108097041-108101870 (+)
BALB/cJ MGP_BALBcJ_G0035232
 protein coding gene Chr9:105134178-105139007 (+)
C3H/HeJ MGP_C3HHeJ_G0034942
 protein coding gene Chr9:108496201-108501030 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035752
 protein coding gene Chr9:112434942-112439776 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032650
 protein coding gene Chr9:102894414-102899224 (+)
CAST/EiJ MGP_CASTEiJ_G0034253
 protein coding gene Chr9:108428856-108433685 (+)
CBA/J MGP_CBAJ_G0034910
 protein coding gene Chr9:116408783-116413617 (+)
DBA/2J MGP_DBA2J_G0035071
 protein coding gene Chr9:104918618-104923452 (+)
FVB/NJ MGP_FVBNJ_G0035019
 protein coding gene Chr9:103683459-103688288 (+)
LP/J MGP_LPJ_G0035147
 protein coding gene Chr9:109649567-109654396 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035058
 protein coding gene Chr9:118021057-118025886 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035773
 protein coding gene Chr9:108368505-108373334 (+)
PWK/PhJ MGP_PWKPhJ_G0033960
 protein coding gene Chr9:105238771-105243600 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033795
 protein coding gene Chr9:108424511-108429360 (+)
WSB/EiJ MGP_WSBEiJ_G0034374
 protein coding gene Chr9:108251641-108256470 (+)



Homology
more
  • Human Ortholog
    HYAL2, hyaluronidase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HYAL2, hyaluronidase 2
  • Synonyms
    LUCA2
  • Links
    NCBI Gene ID: 8692
    neXtProt AC: NX_Q12891
    UniProt: Q12891

  • Chr Location
    3p21.31; chr3:50317790-50322782 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit preweaning lethality, poor survival, craniofacial defects including submucosal cleft palate, and mild anemia. Incompletely penetrant features include cor triatriatum sinister and hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    110
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    880
  • Tissues
    131
  • cDNA Data
    12
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010047 Ensembl Gene Model | MGI Sequence Detail 4835 C57BL/6J ±  kb
    transcript ENSMUST00000010191 Ensembl | MGI Sequence Detail 1893 Not Applicable  
    polypeptide ENSMUSP00000010191 Ensembl | MGI Sequence Detail 473 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 2
      cDNA 13
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143004, MGI:2143243, MGI:2143332
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 11
      Gene Ontology 15
      Phenotypes 16
    • Earliest
      J:50537 Strobl B, et al., Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. Genomics. 1998 Oct 15;53(2):214-9
    • Latest
      J:346912 Huang H, et al., Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells. Matrix Biol. 2024 Mar 13;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory