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Dpagt1 Gene Detail
Summary
  • Symbol
    Dpagt1
  • Name
    dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
  • Synonyms
    Dpagt2, Gnpta, GPT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196396
    NCBI Gene: 13478
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44237316-44245197 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    289 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196396
 protein coding gene Chr9:44237314-44247374 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034701
 protein coding gene Chr9:42808631-42816566 (+)
A/J MGP_AJ_G0034682
 protein coding gene Chr9:41620242-41628050 (+)
AKR/J MGP_AKRJ_G0034608
 protein coding gene Chr9:42479579-42487005 (+)
BALB/cJ MGP_BALBcJ_G0034673
 protein coding gene Chr9:41368155-41375657 (+)
C3H/HeJ MGP_C3HHeJ_G0034384
 protein coding gene Chr9:42935033-42944342 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035194
 protein coding gene Chr9:44078176-44090306 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032109
 protein coding gene Chr9:41199595-41206387 (+)
CAST/EiJ MGP_CASTEiJ_G0033706
 protein coding gene Chr9:42777468-42785668 (+)
CBA/J MGP_CBAJ_G0034356
 protein coding gene Chr9:45682921-45692869 (+)
DBA/2J MGP_DBA2J_G0034515
 protein coding gene Chr9:41522084-41529036 (+)
FVB/NJ MGP_FVBNJ_G0034456
 protein coding gene Chr9:40773155-40783528 (+)
LP/J MGP_LPJ_G0034596
 protein coding gene Chr9:43107542-43115583 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034500
 protein coding gene Chr9:47531379-47538165 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035215
 protein coding gene Chr9:42378138-42385840 (+)
PWK/PhJ MGP_PWKPhJ_G0033412
 protein coding gene Chr9:41394021-41400807 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033246
 protein coding gene Chr9:42699386-42706092 (+)
WSB/EiJ MGP_WSBEiJ_G0033819
 protein coding gene Chr9:42419478-42426183 (+)



Homology
more
  • Human Ortholog
    DPAGT1, dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPAGT1, dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
  • Synonyms
    ALG7, CDG1J, CDG-Ij, CMS13, CMSTA2, D11S366, DGPT, DPAGT, DPAGT2, G1PT, GPT, UAGT, UGAT
  • Links
    NCBI Gene ID: 1798
    neXtProt AC: NX_Q9H3H5
    UniProt: Q9H3H5

  • Chr Location
    11q23.3; chr11:119093874-119108331 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human DPAGT1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display an embryonic lethal phenotype due to widespread cell death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    95
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032123 Ensembl Gene Model | MGI Sequence Detail 7882 C57BL/6J ±  kb
transcript ENSMUST00000054708 Ensembl | MGI Sequence Detail 2205 Not Applicable  
polypeptide ENSMUSP00000056282 Ensembl | MGI Sequence Detail 410 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 105
    Genomic 10
    cDNA 95

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10207, MGI:2143209, MGI:95788
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:47505 Varki A, et al., Demonstration of the heterozygous state for I-cell disease and pseudo-Hurler polydystrophy by assay of N-acetylglucosaminylphosphotransferase in white blood cells and fibroblasts. Am J Hum Genet. 1982 Sep;34(5):717-29
  • Latest
    J:330157 Hyde LF, et al., A Dpagt1 Missense Variant Causes Degenerative Retinopathy without Myasthenic Syndrome in Mice. Int J Mol Sci. 2022 Oct 9;23(19)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory