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Irx1 Gene Detail
Summary
  • Symbol
    Irx1
  • Name
    Iroquois homeobox 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197515
    NCBI Gene: 16371
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:72106351-72111842 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 38.43 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    146 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197515
 protein coding gene Chr13:72106040-72111842 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020739
 protein coding gene Chr13:72306689-72312498 (-)
A/J MGP_AJ_G0020695
 protein coding gene Chr13:69759994-69765791 (-)
AKR/J MGP_AKRJ_G0020670
 protein coding gene Chr13:71975798-71982208 (-)
BALB/cJ MGP_BALBcJ_G0020692
 protein coding gene Chr13:70272281-70278067 (-)
C3H/HeJ MGP_C3HHeJ_G0020487
 protein coding gene Chr13:71682787-71689200 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021129
 protein coding gene Chr13:74773038-74779957 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018697
 protein coding gene Chr13:66607155-66612976 (-)
CAST/EiJ MGP_CASTEiJ_G0020004
 protein coding gene Chr13:70718410-70724071 (-)
CBA/J MGP_CBAJ_G0020445
 protein coding gene Chr13:77631492-77644914 (-)
DBA/2J MGP_DBA2J_G0020571
 protein coding gene Chr13:69606828-69612621 (-)
FVB/NJ MGP_FVBNJ_G0020551
 protein coding gene Chr13:68616577-68623146 (-)
LP/J MGP_LPJ_G0020643
 protein coding gene Chr13:72582846-72589543 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020579
 protein coding gene Chr13:76037864-76045230 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021168
 protein coding gene Chr13:71276431-71282441 (-)
PWK/PhJ MGP_PWKPhJ_G0019758
 protein coding gene Chr13:68320508-68326766 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019581
 protein coding gene Chr13:67745765-67751600 (-)
WSB/EiJ MGP_WSBEiJ_G0020061
 protein coding gene Chr13:71817282-71824312 (-)



Homology
more
  • Human Ortholog
    IRX1, iroquois homeobox 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRX1, iroquois homeobox 1
  • Synonyms
    IRX-5, IRXA1
  • Links
    NCBI Gene ID: 79192
    neXtProt AC: NX_P78414
    UniProt: P78414

  • Chr Location
    5p15.33; chr5:3595832-3601403 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IRX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete neonatal lethality associated with delayed lung maturation, cyanosis, respiratory distress, atelectasis and decreased surfactant secretion, and show defects in dental epithelial cell differentiation and delayed growth of the lower incisors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1587
  • Tissues
    502
  • cDNA Data
    89
  • Literature Summary
    59
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16371 NCBI Gene Model | MGI Sequence Detail 5492 C57BL/6J ±  kb
    transcript NM_010573 RefSeq | MGI Sequence Detail 2080 ZRU/MplStud  
    polypeptide P81068 UniProt | EBI | MGI Sequence Detail 480 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 100
      cDNA 89
      Primer pair 5
      Other 6

      Microarray probesets 4
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 59
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:354246 Zhu S, et al., Follistatin controls the number of murine teeth by limiting TGF-beta signaling. iScience. 2024 Sep 20;27(9):110785
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory