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Otog Gene Detail
Summary
  • Symbol
    Otog
  • Name
    otogelin
  • Synonyms
    Otgn
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202064
    NCBI Gene: 18419
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45890411-45960858 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.66 cM, cytoband B4-C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2731 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202064
 protein coding gene Chr7:45890411-45960858 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032262
 protein coding gene Chr7:46604289-46678526 (+)
A/J MGP_AJ_G0032241
 protein coding gene Chr7:45645336-45717572 (+)
AKR/J MGP_AKRJ_G0032177
 protein coding gene Chr7:46933809-47004064 (+)
BALB/cJ MGP_BALBcJ_G0032253
 protein coding gene Chr7:45651441-45723471 (+)
C3H/HeJ MGP_C3HHeJ_G0031968
 protein coding gene Chr7:47438405-47510297 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032745
 protein coding gene Chr7:48872112-48948109 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029759
 protein coding gene Chr7:48193673-48264684 (+)
CAST/EiJ MGP_CASTEiJ_G0031296
 protein coding gene Chr7:38862906-38932589 (+)
CBA/J MGP_CBAJ_G0031933
 protein coding gene Chr7:50514368-50587202 (+)
DBA/2J MGP_DBA2J_G0032090
 protein coding gene Chr7:45342158-45413400 (+)
FVB/NJ MGP_FVBNJ_G0032042
 protein coding gene Chr7:45126916-45197982 (+)
LP/J MGP_LPJ_G0032169
 protein coding gene Chr7:47300038-47373408 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032079
 protein coding gene Chr7:49148864-49222579 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032760
 protein coding gene Chr7:46147593-46222671 (+)
PWK/PhJ MGP_PWKPhJ_G0031019
 protein coding gene Chr7:38706120-38778146 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030857
 protein coding gene Chr7:34160799-34234416 (+)
WSB/EiJ MGP_WSBEiJ_G0031414
 protein coding gene Chr7:46640784-46720131 (+)



Homology
more
  • Human Ortholog
    OTOG, otogelin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OTOG, otogelin
  • Synonyms
    DFNB18B, MLEMP, OTGN
  • Links
    NCBI Gene ID: 340990
    neXtProt AC: NX_Q6ZRI0
    UniProt: Q6ZRI0

  • Chr Location
    11p15.1; chr11:17547259-17647150 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Otog mouse models; 1 with human OTOG associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 8 alleles in 8 genetic backgrounds
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a number of different spontaneous and targeted mutations exhibit vestibular dysfunction, including circling, head tilt, impaired balance, coordination, and placing response. Mutants have impaired hearing, decreased brain stem auditory evoked potential, and ear abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    45
  • cDNA Data
    5
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18419 NCBI Gene Model | MGI Sequence Detail 70448 C57BL/6J ±  kb
    transcript NM_013624 RefSeq | MGI Sequence Detail 10043 Not Specified  
    polypeptide O55225 UniProt | EBI | MGI Sequence Detail 2911 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 2
      cDNA 5
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15306, MGI:98873
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:28402 Li X, et al., Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci. Genomics. 1995 Aug 10;28(3):442-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory