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Gas8 Gene Detail
Summary
  • Symbol
    Gas8
  • Name
    growth arrest specific 8
  • Synonyms
    Gas11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202386
    NCBI Gene: 104346
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:124245630-124263394 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.10 cM, cytoband E2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    527 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202386
 protein coding gene Chr8:124245573-124263394 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034259
 protein coding gene Chr8:127124939-127142749 (+)
A/J MGP_AJ_G0034239
 protein coding gene Chr8:121896713-121914758 (+)
AKR/J MGP_AKRJ_G0034166
 protein coding gene Chr8:125398794-125417671 (+)
BALB/cJ MGP_BALBcJ_G0034232
 protein coding gene Chr8:122077614-122095437 (+)
C3H/HeJ MGP_C3HHeJ_G0033943
 protein coding gene Chr8:126101679-126121698 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034752
 protein coding gene Chr8:131411246-131429104 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031694
 protein coding gene Chr8:114677908-114696915 (+)
CAST/EiJ MGP_CASTEiJ_G0033271
 protein coding gene Chr8:126209760-126230291 (+)
CBA/J MGP_CBAJ_G0033916
 protein coding gene Chr8:136208045-136228961 (+)
DBA/2J MGP_DBA2J_G0034072
 protein coding gene Chr8:121052347-121070156 (+)
FVB/NJ MGP_FVBNJ_G0034016
 protein coding gene Chr8:120206525-120224356 (+)
LP/J MGP_LPJ_G0034162
 protein coding gene Chr8:127269850-127287665 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034063
 protein coding gene Chr8:138357293-138375347 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034771
 protein coding gene Chr8:125621514-125639438 (+)
PWK/PhJ MGP_PWKPhJ_G0032972
 protein coding gene Chr8:120874147-120894425 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032812
 protein coding gene Chr8:124339294-124363075 (+)
WSB/EiJ MGP_WSBEiJ_G0033387
 protein coding gene Chr8:126354227-126372079 (+)



Homology
more
  • Human Ortholog
    GAS8, growth arrest specific 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAS8, growth arrest specific 8
  • Synonyms
    CILD33, DRC4, GAS11
  • Links
    NCBI Gene ID: 2622
    neXtProt AC: NX_O95995
    UniProt: O95995

  • Chr Location
    16q24.3; chr16:90019629-90044975 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gas8 mouse models; 1 with human GAS8 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit postnatal lethality, severe hydrocephaly, situs inversus with levocardia and abnormal cilia morphology and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    11
  • cDNA Data
    37
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104346 NCBI Gene Model | MGI Sequence Detail 17765 C57BL/6J ±  kb
    transcript NR_189740 RefSeq | MGI Sequence Detail 1708 C57BL/6  
    polypeptide Q60779 UniProt | EBI | MGI Sequence Detail 478 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 1
      cDNA 37

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1933195
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 14
      Phenotypes 5
    • Earliest
      J:46329 Brenner DG, et al., Analysis of mammalian cell genetic regulation in situ by using retrovirus-derived portable exons carrying the Escherichia coli lacZ gene. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5517-21
    • Latest
      J:343289 Ho KH, et al., Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage. Dev Cell. 2023 Dec 4;58(23):2641-2651.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory