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Meig1 Gene Detail
Summary
  • Symbol
    Meig1
  • Name
    meiosis expressed gene 1
  • Synonyms
    Meg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202878
    NCBI Gene: 104362
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:3410080-3423685 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 1.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    421 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202878
 protein coding gene Chr2:3410080-3423685 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025307
 protein coding gene Chr2:380029-393587 (-)
A/J MGP_AJ_G0025283
 protein coding gene Chr2:360973-374578 (-)
AKR/J MGP_AKRJ_G0025252
 protein coding gene Chr2:370311-383916 (-)
BALB/cJ MGP_BALBcJ_G0025279
 protein coding gene Chr2:352184-365783 (-)
C3H/HeJ MGP_C3HHeJ_G0025039
 protein coding gene Chr2:381064-394663 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025722
 protein coding gene Chr2:374222-387827 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023136
 protein coding gene Chr2:308401-322268 (-)
CAST/EiJ MGP_CASTEiJ_G0024503
 protein coding gene Chr2:381537-395089 (-)
CBA/J MGP_CBAJ_G0025019
 protein coding gene Chr2:400776-414381 (-)
DBA/2J MGP_DBA2J_G0025150
 protein coding gene Chr2:345866-359471 (-)
FVB/NJ MGP_FVBNJ_G0025112
 protein coding gene Chr2:354835-368907 (-)
LP/J MGP_LPJ_G0025237
 protein coding gene Chr2:382608-396158 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025145
 protein coding gene Chr2:376848-394365 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025780
 protein coding gene Chr2:369585-383263 (-)
PWK/PhJ MGP_PWKPhJ_G0024252
 protein coding gene Chr2:344560-358264 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024054
 protein coding gene Chr2:398527-412073 (-)
WSB/EiJ MGP_WSBEiJ_G0024573
 protein coding gene Chr2:377556-391161 (-)



Homology
more
  • Human Ortholog
    MEIG1, meiosis/spermiogenesis associated 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEIG1, meiosis/spermiogenesis associated 1
  • Synonyms
    bA2K17.3, SPATA39
  • Links
    NCBI Gene ID: 644890
    neXtProt AC: NX_Q5JSS6
    UniProt: Q5JSS6

  • Chr Location
    10p13; chr10:14954228-14988050 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 5 genetic backgrounds
    2 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male sterility with arrested spermatogenesis, absent sperm flagellum, and deformed sperm heads.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    6
  • cDNA Data
    148
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104362 NCBI Gene Model | MGI Sequence Detail 13606 C57BL/6J ±  kb
    transcript NM_001355205 RefSeq | MGI Sequence Detail 852 C57BL/6  
    polypeptide Q61845 UniProt | EBI | MGI Sequence Detail 88 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 153
      cDNA 148
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12188, MGI:96959
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 7
      Phenotypes 43
    • Earliest
      J:2557 Don J, et al., Identification and characterization of the regulated pattern of expression of a novel mouse gene, meg1, during the meiotic cell cycle. Cell Growth Differ. 1992 Aug;3(8):495-505
    • Latest
      J:331385 Yao W, et al., Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment. JCI Insight. 2022 Nov 8;7(21)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory