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Endog Gene Detail
Summary
  • Symbol
    Endog
  • Name
    endonuclease G
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261433
    NCBI Gene: 13804
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:30061525-30064057 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.29 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    194 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261433
 protein coding gene Chr2:30061505-30064081 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025556
 protein coding gene Chr2:28392542-28395118 (+)
A/J MGP_AJ_G0025534
 protein coding gene Chr2:27255955-27258531 (+)
AKR/J MGP_AKRJ_G0025503
 protein coding gene Chr2:28184445-28187021 (+)
BALB/cJ MGP_BALBcJ_G0025530
 protein coding gene Chr2:27384260-27386836 (+)
C3H/HeJ MGP_C3HHeJ_G0025291
 protein coding gene Chr2:28112636-28115212 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025975
 protein coding gene Chr2:29328265-29330841 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023383
 protein coding gene Chr2:26048426-26050956 (+)
CAST/EiJ MGP_CASTEiJ_G0024753
 protein coding gene Chr2:28004856-28007444 (+)
CBA/J MGP_CBAJ_G0025268
 protein coding gene Chr2:30321647-30324226 (+)
DBA/2J MGP_DBA2J_G0025401
 protein coding gene Chr2:27040962-27043538 (+)
FVB/NJ MGP_FVBNJ_G0025364
 protein coding gene Chr2:26857441-26860017 (+)
LP/J MGP_LPJ_G0025487
 protein coding gene Chr2:28298609-28301185 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025394
 protein coding gene Chr2:30217749-30220325 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026033
 protein coding gene Chr2:28098248-28100824 (+)
PWK/PhJ MGP_PWKPhJ_G0024500
 protein coding gene Chr2:26885332-26887941 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024300
 protein coding gene Chr2:28191600-28194137 (+)
WSB/EiJ MGP_WSBEiJ_G0024821
 protein coding gene Chr2:28230589-28233212 (+)



Homology
more
  • Human Ortholog
    ENDOG, endonuclease G
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENDOG, endonuclease G
  • Links
    NCBI Gene ID: 2021
    neXtProt AC: NX_Q14249
    UniProt: Q14249

  • Chr Location
    9q34.11; chr9:128818500-128822676 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and have no detectable abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    23
  • cDNA Data
    8
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13804 NCBI Gene Model | MGI Sequence Detail 2533 C57BL/6J ±  kb
    transcript NR_184725 RefSeq | MGI Sequence Detail 1403 C57BL/6  
    polypeptide O08600 UniProt | EBI | MGI Sequence Detail 294 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 6
      cDNA 8
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 4
      Gene Ontology 14
      Phenotypes 16
    • Earliest
      J:43924 Prats E, et al., Characterization and expression of the mouse endonuclease G gene. DNA Cell Biol. 1997 Sep;16(9):1111-22
    • Latest
      J:351285 Zhu C, et al., Caspase-3 promotes oncogene-induced malignant transformation via EndoG-dependent Src-STAT3 phosphorylation. Cell Death Dis. 2024 Jul 9;15(7):486
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory