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Tbx10 Gene Detail
Summary
  • Symbol
    Tbx10
  • Name
    T-box 10
  • Synonyms
    Tbx13, Tbx7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261436
    NCBI Gene: 109575
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr19:4042752-4049512 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.71 cM, cytoband A
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261436
 protein coding gene Chr19:4042752-4049512 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024637
 protein coding gene Chr19:811436-818195 (+)
A/J MGP_AJ_G0024605
 protein coding gene Chr19:771101-777860 (+)
AKR/J MGP_AKRJ_G0024576
 protein coding gene Chr19:801619-808378 (+)
BALB/cJ MGP_BALBcJ_G0024603
 protein coding gene Chr19:782818-789577 (+)
C3H/HeJ MGP_C3HHeJ_G0024371
 protein coding gene Chr19:799419-807795 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025051
 protein coding gene Chr19:820100-826859 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022480
 protein coding gene Chr19:736478-742896 (+)
CAST/EiJ MGP_CASTEiJ_G0023843
 protein coding gene Chr19:810968-820725 (+)
CBA/J MGP_CBAJ_G0024342
 protein coding gene Chr19:901034-907793 (+)
DBA/2J MGP_DBA2J_G0024470
 protein coding gene Chr19:749522-756281 (+)
FVB/NJ MGP_FVBNJ_G0024437
 protein coding gene Chr19:762314-769067 (+)
LP/J MGP_LPJ_G0024557
 protein coding gene Chr19:810271-818486 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024468
 protein coding gene Chr19:855666-862396 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025099
 protein coding gene Chr19:794419-801178 (+)
PWK/PhJ MGP_PWKPhJ_G0023590
 protein coding gene Chr19:787305-794053 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023396
 protein coding gene Chr19:791692-798443 (+)
WSB/EiJ MGP_WSBEiJ_G0023906
 protein coding gene Chr19:786669-793424 (+)



Homology
more
  • Human Ortholog
    TBX10, T-box transcription factor 10
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBX10, T-box transcription factor 10
  • Synonyms
    TBX13, TBX7
  • Links
    NCBI Gene ID: 347853
    neXtProt AC: NX_O75333
    UniProt: O75333

  • Chr Location
    11q13.2; chr11:67631303-67641754 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 2 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gain of function mutation die perinatally with cleft lip and cleft palate; heterozygotes show penetrance and strain effects - they generally circle and head-toss, but are not deaf, lack the macula of utriculus and show defects of the labyrinths in the vestibular region.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    819
  • Tissues
    71
  • cDNA Data
    12
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109575 NCBI Gene Model | MGI Sequence Detail 6761 C57BL/6J ±  kb
    transcript NM_001001320 RefSeq | MGI Sequence Detail 1795 ZRU/MplStud  
    polypeptide Q810F8 UniProt | EBI | MGI Sequence Detail 385 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 12
      Primer pair 1
      Other 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-8807, MGI:1201667, MGI:94868
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 14
      Gene Ontology 3
      Phenotypes 20
    • Earliest
      J:5022 Deol MS, et al., A new gene affecting the morphogenesis of the vestibular part of the inner ear in the mouse. J Embryol Exp Morphol. 1966 Dec;16(3):543-58
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory