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Suz12 Gene Detail
Summary
  • Symbol
    Suz12
  • Name
    SUZ12 polycomb repressive complex 2 subunit
  • Synonyms
    2610028O16Rik, D11Ertd530e, mKIAA0160
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261758
    NCBI Gene: 52615
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:79883932-79924949 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 47.36 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1130 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261758
 protein coding gene Chr11:79883932-79924949 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018803
 protein coding gene Chr11:81122369-81167757 (+)
A/J MGP_AJ_G0018770
 protein coding gene Chr11:78009266-78053563 (+)
AKR/J MGP_AKRJ_G0018740
 protein coding gene Chr11:80358062-80401307 (+)
BALB/cJ MGP_BALBcJ_G0018743
 protein coding gene Chr11:78396411-78442072 (+)
C3H/HeJ MGP_C3HHeJ_G0018557
 protein coding gene Chr11:80402627-80448670 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019195
 protein coding gene Chr11:83609731-83656438 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016829
 protein coding gene Chr11:74944194-74988426 (+)
CAST/EiJ MGP_CASTEiJ_G0018112
 protein coding gene Chr11:80875776-80921485 (+)
CBA/J MGP_CBAJ_G0018528
 protein coding gene Chr11:87261494-87306702 (+)
DBA/2J MGP_DBA2J_G0018636
 protein coding gene Chr11:77562590-77609650 (+)
FVB/NJ MGP_FVBNJ_G0018625
 protein coding gene Chr11:77136851-77180088 (+)
LP/J MGP_LPJ_G0018706
 protein coding gene Chr11:81637559-81690776 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018652
 protein coding gene Chr11:87543561-87591645 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019235
 protein coding gene Chr11:80599287-80647359 (+)
PWK/PhJ MGP_PWKPhJ_G0017882
 protein coding gene Chr11:78370683-78415053 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017673
 protein coding gene Chr11:80198807-80238048 (+)
WSB/EiJ MGP_WSBEiJ_G0018164
 protein coding gene Chr11:80435869-80480846 (+)



Homology
more
  • Human Ortholog
    SUZ12, SUZ12 polycomb repressive complex 2 subunit
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUZ12, SUZ12 polycomb repressive complex 2 subunit
  • Synonyms
    CHET9, IMMAS, JJAZ1
  • Links
    NCBI Gene ID: 23512
    neXtProt AC: NX_Q15022
    UniProt: Q15022

  • Chr Location
    17q11.2; chr17:31937007-32001038 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SUZ12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 4 alleles in 5 genetic backgrounds
    26 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die during early postimplantation stages with failure of embryonic and extraembyronic tissues and organogenesis. Mice heterozygous for a knock-out allele exhibit abnormal brain and spinal cord development with varying penetrance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    915
  • Tissues
    96
  • cDNA Data
    23
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 52615 NCBI Gene Model | MGI Sequence Detail 41018 C57BL/6J ±  kb
    transcript NM_199196 RefSeq | MGI Sequence Detail 4449 ZRU/MplStud  
    polypeptide Q80U70 UniProt | EBI | MGI Sequence Detail 741 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 24
      Primer pair 7
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1922065, MGI:2144085, MGI:2144379, MGI:2144551
    References
    more
    • Summaries
      All 138
      Developmental Gene Expression 34
      Gene Ontology 36
      Phenotypes 37
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:346895 Guo P, et al., A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis. Elife. 2024 Feb 12;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory