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Usp12 Gene Detail
Summary
  • Symbol
    Usp12
  • Name
    ubiquitin specific peptidase 12
  • Synonyms
    Ubh1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270128
    NCBI Gene: 22217
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:146671619-146731816 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 86.00 cM, cytoband G2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1523 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270128
 protein coding gene Chr5:146671619-146731817 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030378
 protein coding gene Chr5:152346791-152402717 (-)
A/J MGP_AJ_G0030351
 protein coding gene Chr5:145898540-145953640 (-)
AKR/J MGP_AKRJ_G0030278
 protein coding gene Chr5:150370660-150427717 (-)
BALB/cJ MGP_BALBcJ_G0030360
 protein coding gene Chr5:147113097-147166142 (-)
C3H/HeJ MGP_C3HHeJ_G0030074
 protein coding gene Chr5:151317250-151374651 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030815
 protein coding gene Chr5:157907245-157969248 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028028
 protein coding gene Chr5:140314417-140369062 (-)
CAST/EiJ MGP_CASTEiJ_G0029476
 protein coding gene Chr5:150868592-150931791 (-)
CBA/J MGP_CBAJ_G0030052
 protein coding gene Chr5:164506555-164562042 (-)
DBA/2J MGP_DBA2J_G0030196
 protein coding gene Chr5:145577786-145634863 (-)
FVB/NJ MGP_FVBNJ_G0030150
 protein coding gene Chr5:144770056-144826577 (-)
LP/J MGP_LPJ_G0030283
 protein coding gene Chr5:153038232-153098444 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030186
 protein coding gene Chr5:166809455-166870528 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030845
 protein coding gene Chr5:150279030-150334029 (-)
PWK/PhJ MGP_PWKPhJ_G0029190
 protein coding gene Chr5:144648644-144705315 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029026
 protein coding gene Chr5:147582368-147636191 (-)
WSB/EiJ MGP_WSBEiJ_G0029553
 protein coding gene Chr5:151064647-151128174 (-)



Homology
more
  • Human Ortholog
    USP12, ubiquitin specific peptidase 12
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP12, ubiquitin specific peptidase 12
  • Synonyms
    UBH1, USP12L1
  • Links
    NCBI Gene ID: 219333
    neXtProt AC: NX_O75317
    UniProt: O75317

  • Chr Location
    13q12.13; chr13:27066156-27171811 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    12
  • cDNA Data
    76
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029640 Ensembl Gene Model | MGI Sequence Detail 60198 C57BL/6J ±  kb
    transcript ENSMUST00000085614 Ensembl | MGI Sequence Detail 4327 Not Applicable  
    polypeptide ENSMUSP00000082754 Ensembl | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 77
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:47937 Hansen-Hagge TE, et al., An evolutionarily conserved gene on human chromosome 5q33-q34, UBH1, encodes a novel deubiquitinating enzyme. Genomics. 1998 May 1;49(3):411-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory